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肝硬化干细胞移植治疗中自体骨髓采集临床研究 被引量:1

Collection of autologous bone marrow in stem cell transplantation for liver cirrhosis
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摘要 目的探讨肝硬化患者自体骨髓采集过程的临床表现。方法 122例行自体骨髓采集的肝硬化患者,比较采集前5min、局部麻醉、穿刺术中及术后15min患者心率、收缩压、舒张压变化;比较前3管骨髓采集中患者疼痛评分及每管抽取时间。结果以双侧髂后上嵴为骨髓采集部位,局部麻醉、穿刺及抽取骨髓过程中患者心率均高于术前(P<0.05),收缩压、舒张压与术前比较差异无统计学意义(P>0.05),术后15min收缩压、舒张压低于术前(P<0.05)、但在正常范围,心率与术前比较差异无统计学意义(P>0.05);双侧局部麻醉时疼痛程度评分差异无统计学意义(P>0.05),右侧穿刺时疼痛程度评分高于左侧(P<0.05),抽取双侧第1管骨髓时疼痛程度评分高于第2,3管(P<0.05)。结论正确掌握穿刺方法及抽取速度,可采集较高数量和质量的自体骨髓干细胞。 Objective To explore the clinical manifestations of liver cirrhosis in autologous bone marrow collection.Methods A total of 122 cases of liver cirrhosis receiving autologous bone marrow collection were compared the changes of heart rate,systolic blood pressure and diastolic blood pressure before operation,during local anesthesia,during puncture process and 15 minutes after operation.The pain scores and bone marrow extraction time of the first three tubes in bone marrow collection process were compared.Results The heart rate was higher under local anesthesia,during puncture process and during the extraction process than that before operation(P0.05).The systolic blood pressure and diastolic blood pressure levels did not differ under local anesthesia and during puncture and extraction process compared with before operation(P0.05).The systolic blood pressure and diastolic blood pressure were lower after operation than those before operation(P0.05),and there was no significant difference in heart rate between before and after operation(P0.05).There was no significant difference in pain score of puncture under local anesthesia between two sides(P0.05).The pain score in bilateral of the first tube extraction was higher than that of the second and third tube exaction(P0.05).Conclusion Correct puncture method and bone marrow exacting speed can collect large quantity and high quality of bone marrow stem cell.
机构地区 解放军第
出处 《中华实用诊断与治疗杂志》 2012年第4期324-325,328,共3页 Journal of Chinese Practical Diagnosis and Therapy
基金 四川省卫生厅科研课题(100193)
关键词 肝硬化 骨髓采集 干细胞 Liver cirrhosis bone marrow collection stem cell
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  • 1Li TZ, Kim JH, Cho HH, et al. Therapeutic potential of bone-marrow- derived mesenchymal stem cells differentiated with growth-factor-free coculture method in liver-injured rats [ J ]. Tissue E ng Part A,2010,16 ( 8 ) :2649-2659.
  • 2Stutchfield BM, Forbes SJ, Wigmore SJ. Prospects for stem cell trans- plantation in the treatment of hepatic disease . Liver Transpl,2010, 16(7) :827-836.
  • 3Kisseleva T, Gigante E, Brenner DA. Recent advances in liver stem cell therapy [ J]. Curt Opin Gastroentero1,2010,26 (4) :395-402.
  • 4Madhava P, Zaeharoulis D, Miroslav N, et al. Autologous Infusion of expanded mobilized adult bone marrow-derived CD34 + cells into pa- tients with alcoholic liver cirrhosis [ J ]. Am J Gastroenter, 2008,103 (8) :1952-1958.
  • 5Gilchrist ES, Plevris JN. Bone marrow-derived stem cells in liver re- pair: 10 years down the line [ J ]. Liver Transpl, 2010, 1 6 : 11 8-129.
  • 6Zhang L, Peng X,Zhang Z, et al. Subcellular proteome analysis unrav- eled annexin A2 related to immune liver fibrosis[ J]. J Cell Biochem, 2010,110( 1 ) :219-228.
  • 7Ismail A, Fouad O, Abdelnasser A, et al. Stem cell therapy improves the outcome of liver resection in cirrhotics [ J ]. J Gastrointest Cancer, 2010,41 ( 1 ) :17-23.
  • 8Sakaida I. Autologous bone marrow cell infusion therapy for liver cir- rhosis [ J ]. J Gastroenterol Hepato1,2008,239 ( 9 ) : 1349-1353.
  • 9郭晓钟,王迪,邵晓冬,赵佳军,李宏宇,崔忠敏,刘峰.自体骨髓干细胞移植治疗失代偿期肝硬化[J].中华消化杂志,2009,29(7):433-436. 被引量:30
  • 10刘晓天.自体骨髓干细胞移植介入治疗肝硬化的临床研究[J].齐齐哈尔医学院学报,2010,31(10):1539-1540. 被引量:6

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