他达拉非半量隔日口服治疗ED的疗效观察

Clinical efficiency of interval day oral half dose of tadalafil on treatment of ED

目的:评估他达拉非半量(10 mg)隔日口服治疗勃起功能障碍(ED)的疗效。方法:选择158例符合美国国立卫生研究院诊断标准的ED患者,随机分为他达拉非(希爱力)组和复方玄驹胶囊组两组,分别接受3个月的治疗,治疗后各组又随访3个月以上。采用勃起功能障碍症状评分(international index of erectilefunction-5,IIEF-5)评估治疗前后及继续随访3个月后各组的疗效,同时比较患者性生活日记中插入成功率和性交中保持勃起至完成性交的成功率。采用焦虑自评量表评价焦虑状态。结果:治疗前两组IIEF-5评分分别为(9.96±4.21)、(9.69±4.35)分,差异无统计学意义(P>0.05)。治疗3个月后IIEF-5评分分别为(20.38±4.18)、(16.08±3.26)分,随访至6个月时IIEF-5评分分别为(18.16±2.31)、(11.98±3.97)分,差异均有统计学意义(P<0.01),而且两组间在治疗后和6个月随访时的评分差异也具有统计学意义(P<0.05)。药物治疗后,患者性生活日记中插入成功率和保持勃起的成功率明显提高,希爱力组高于复方玄驹胶囊组。焦虑评分值两组治疗后明显低于治疗前(P<0.05)。结论:他达拉非隔日半量口服可有效治疗ED,且疗效优于传统中药,可作为临床上的一线治疗方法。

Objective：To evaluate the clinical efficiency of interval day oral half dose of tadalafil on treatment of erectile dysfunction（ED）.Methods：Total of 158 cases ED patients were divided into 2 groups randomly including tadalafil（cialis） group and FuFangXuanJu Capsule group.International index of erectile function-5（IIEF-5） scores of patients in each group were recorded and compared before and after 3-months treatment and 3-months discontinuing the drug and the satisfaction degree of coitus in patients diary and anxiety symptoms（SAS score） of all patients were also comparatively analyzed.Results：Before treatment,the IIEF-5 scores of two groups were 9.96±4.21 and 9.69±4.35 respectively and no significant difference was found between two groups（P0.05）.After treatment,the IIEF-5 scores were 20.38±4.18 and 16.08±3.26 respectively,and 3-months after discontinuing the drug,the IIEF-5 scores were 18.16±2.31 and 11.98±3.97 respectively.There were significant differences between pre-treatment and post-treatment（P0.01）.A significant difference in IIEF-5 scores was also found in two groups post treatment and 3-months after discontinuing the drug（P0.05）.Tadalafil was shown to be better in improving satisfaction degree of coitus and SAS score of two groups after treatment was significantly lower than that of pre-treatment（P0.05）.Conclusion：For treatment of ED,clinical efficiency of interval day oral half dose of tadalafil is superior to that FuFangXuanJu Capsule and should be recommended to be a better option in therapy of ED.