563株肺炎克雷伯杆菌临床分布及耐药性分析

Distribution and drug-resistance of 563 strains of Klebsiella pneumoniae

目的调查我院2006年1月至2010年12月分离的肺炎克雷伯杆菌的耐药趋势,为临床治疗提供可靠依据。方法收集送检标本中分离的肺炎克雷伯杆菌株,按全国临床检验规程分离鉴定,并采用KB法进行药敏试验,用WHONET5.4软件进行统计分析。结果本院5年间共分离出563株肺炎克雷伯杆菌,以痰标本分离率最高(64.48%)。肺炎克雷伯杆菌对亚胺培南和美罗培南的耐药率为0%,对氨苄青霉素的耐药率高达98%以上;对庆大霉素、头孢呋肟钠、头孢西丁的耐药率总体上呈上升趋势。结论对肺炎克雷伯杆菌进行及时鉴定和药敏分析,把握其耐药趋势,可有效指导临床合理用药。

Objective To investigate the tendency of drug-resistance of Klebsiella pneumoniae（K.pneumoniae） isolated from our hospital during 5 years,and to provide reliable evidence for clinical treatment.Methods K.pneumoniae strains isolated from the specimens were collected,separated and identified according to The national clinical test procedures.The antimicrobial susceptibility test was performed by KB method,and statistical analysis was carried out by using WHONET5.4 software.Results A total of 563 K.pneumonia strains have been isolated,most of which were derived from sputum.The drug-resistance rates of K.pneumonia against Imipenem and Meropenem was both 0%,while that against Ampicillin was up to 98%.The drug-resistance rates of K.pneumonia against Cefuroxime sodium,Gentamicin,cefotaxime were on the rise.Conclusion It is effective to direct reasonable clinical medication by making timely identification and antimicrobial susceptibility analysis,and acquiring the tendency of drug-resistance of K.pneumonia.