10天序贯疗法与传统三联疗法根除幽门螺旋杆菌的疗效观察

Efficacy observation of 10 days sequential therapy and conventional triple therapy for eradication of Helicobacter pylori infection

目的观察由埃索美拉唑、阿莫西林、克拉霉素、替硝唑组成的10 d序贯疗法根除幽门螺旋杆菌的疗效与安全性。方法选取150例14C尿素呼气试验阳性病例,随机分为2组:治疗组前5 d予埃索美拉唑、阿莫西林,后5 d予埃索美拉唑、替硝唑、克拉霉素治疗;对照组予埃索美拉唑、克拉霉素、阿莫西林治疗10 d。治疗结束后,间隔4周行14C尿素呼气试验,复查Hp,评价治疗效果。结果治疗组Hp根除率为89.74%,对照组为75.0%,两组Hp根除率比较具有统计学意义(P<0.05)。结论以埃索美拉唑、阿莫西林、克拉霉素、替硝唑组成的10 d序贯疗法根除Hp感染疗效优于传统三联疗法。

Objective To observe the efficacy and safety of esomeprazole,amoxicillin,clarithromycin,and tinidazole on the 10th of sequential therapy to eradicate Helicobacter pylori.Methods 150 cases of 14C urea breath test positive were randomly divided into two groups：treatment group,five days before to esomeprazole,amoxicillin,five days after to esomeprazole,tinidazole,clarithromycin treatment;control group to esomeprazole,clarithromycin,and amoxicillin treatment for 10 days.The end of the treatment after an interval of four weeks of 14C urea breath test,review Hp to evaluate the therapeutic effect.Results Hp eradication rate of treatment group was 89.74%,while control group was 75.0%,there was significant difference between the two groups（P0.05）.Conclusion The 10 days of sequential therapy consisting of esomeprazole,amoxicillin,clarithromycin,and tinidazole to eradicate Hp infection was more effective than triple therapy.