房颤患者左心房内径与血浆内脂素、脂联素水平的关系及临床意义

The relationship between the left atrium diameter and plasma levels of visfation,adiponection in atrial fibrillation patients and its clinical significant

目的研究房颤患者左心房内径(LAD)与血浆内脂素、脂联素(APN)的变化,探讨其临床意义。方法选择42例符合诊断要求的心内科住院心房颤动(房颤)患者,根据2006年ACC/AHA房颤指南中房颤分类标准,分为阵发性房颤组22例(房颤持续时间<7d)和持续性房颤组20例(房颤持续时间≥7d),另选择同时期心内科住院无房颤患者15例作为对照组,比较各组间内脂素、APN、LAD变化。结果 (1)持续性房颤组较阵发性房颤组和对照组血浆内脂素、APN水平明显升高(P<0.05);阵发性房颤组、对照组血浆内脂素、APN水平差异无统计学意义(P>0.05);(2)持续性房颤组较阵发性房颤组和对照组LAD增大(P<0.05);(3)LAD与血浆内脂素水平呈正相关(r=0.417,P<0.05)。结论高内脂素、APN水平,LAD增大与房颤的持续存在相关,内脂素、APN、LAD可用来预测房颤的转归,指导房颤治疗。

Objective To evaluate the significance of left atrial diameter（LAD） and visfatin,adiponection（APN） in atrial fibrillation（AF） patients.Methods 42 AF patients were divided into two groups basing on AF guideline of ACC/ AHA 2006.Paroxysmal AF group included 22 patients and persistent AF group with 20 patients.Control group included 15 patients who were admitted to hospital in cardiology department without AF.Plasma visfatin,APN levels and LAD were measured and compared among the three groups.Results Visfatin and APN levels in persistent AF group were significantly higher than that in control group and paroxysmal AF group（P0.05）;LAD in persistent AF group was larger than that in control group and paroxysmal AF group（P0.05）,meanwhile,there were no difference between paroxymal AF group and control group（P 0.05）.There were correlation between LAD and visfatin（r=0.417,P0.05）.Conclusion The elevation of plasma visfatin,APN and LAD size were associated with AF,visfatin,APN and LAD maybe predictor for guiding AF therapy.