132株奇异变形杆菌的临床分布及药敏分析

Clinical distribution and drug sensitivity analysis of 132 strains of Proteus mirabilis

目的了解宁波市妇女儿童医院奇异变形杆菌的临床分布和耐药情况,为临床合理用药提供依据。方法对该院2009年6月1日至2011年5月31日期间分离的132株奇异变形杆菌进行分析,菌株鉴定采用法国生物梅里埃公司的VITEK 60分析仪,药敏试验采用K-B法,用参考菌株作质量控制。结果该院分离的奇异变形杆菌主要来自尿液(51.50%),其次是创口分泌物(21.21%),再次是阴道分泌物(19.70%),其他(7.59%)。对奇异变形杆菌敏感率较高的抗生素是:丁胺卡那霉素、氨曲南、美罗培南、亚胺培南、头孢唑林、头孢呋辛酯、头孢曲松、头孢他啶、头孢噻肟、马斯平、头孢西丁、罗红霉素、氨苄西林/舒巴坦、哌拉西林/他唑巴坦和头孢哌酮/舒巴坦。结论加强奇异变形杆菌的分离鉴定及耐药性的测定,是临床合理应用抗生素的重要依据。

Objective To study the clinical distribution and drug resistance of Proteus mirabilis isolated in Ningbo Women and Children＇s Hospital,and provide guidance for clinical medication.Method The authors collected 132 strains of Proteus mirabilis isolated from their hospital during June 1,2009 to May 31,2011.The clinical isolates were identified by VITEK-60 of Bio-Merieux of France.Antibiotic susceptivity test was done by Kirby-Bauer method.And quality control was done with reference strains.Result Most of the clinical specimens came from urine（51.50%）,followed by wound secretion（21.21%）,vaginal discharge（19.70%）,and others（7.59%）.Proteus mirabilis was more sentive to the following antibiotics： Amikacin,Aztreonam,Meropenem,Imipenem,Cefazolin,Cefuroxime axetil,Ceftriaxone,Ceftazidime,Cefotaxime,Maxipime,Cefoxitin,Roxithromycin,Ampicillin/sulbactam,Piperacillin/tazobactam,and Cefoperazone/sulbactam,respectively.Conclusion It is important to strengthen the separation,identification and resistance test of Proteus mirabilis to guide clinical selection of antibiotics.