他汀类药物对缺血性脑血管病患者血浆同型半胱氨酸的影响

Effect of statins on the plasma homocysteic acid of patients with ischemic cerebrovascular disease

目的探讨他汀类药物对缺血性卒脑血管病患者血浆同型半胱氨酸水平的影响。方法将83例新发缺血性脑卒中患者随机分为他汀治疗组和对照组,治疗组入院后给予他汀类药物,对照组不给予,其余治疗完全同治疗组。观察两组血同型半胱氨酸水平变化。结果他汀治疗组血同型半胱氨酸水平和对照组比较差异有统计学意义(P<0.05)。结论他汀类药物除了常规用于降血脂治疗,还可降低缺血性脑血管病患者血同型半胱氨酸水平。

Objective To observe the effect of stains on the plasma homocysteic acid of patients with ischemic cerebrovascular disease. Methods Eighty-three patients with ischemic stroke were divided into control group and therapy group. Statins were givien to the therapy group. The treatment of control group was similar to the therapy group except statins. The changs of plasma homocysteic acid were detected and compared between the two groups. Results Significant differences were detected between the control group and therapy group in plasma homocysteic acid （P 〈 0.05）. Conclusion Stains can not only reduce the blood-fat, but also diminish the plasma homocysteic acid of patients with ischemic cerebrovascular disease.