自组装多肽支架材料的研究进展

Research Advances in Self-assembling Peptide Scaffolds

多肽分子可以利用氢键、疏水性作用、π-π堆积作用等非共价键力自组装形成形态与结构特异的多肽分子聚集体,如分子积木、分子开关、分子涂料及纳米纤维等,由于多肽分子良好的生物相容性和可调控的降解性,自组装多肽在组织工程、药物缓释等方面表现出巨大的应用潜力。本文总体介绍了多肽自组装的几种结构模型及自组装的设计原则,重点叙述了自组装多肽作为组织工程支架材料的研究进展。

Peptide can self assemble through the noncovalent bond action,such as hydrogen bond,hydrophobicity and π-π accumulation,and form different peptide molecular aggregations,for example,molecular brick,molecular switch,molecular paint and nanofiber.These self-assembling peptides are characterized by their good biocompatibility and regulatory biodegradation.So it is a potential biomaterial in the field of tissue engineering and sustained drug delivery systems.In this paper,we describe several structure models made from self-assembling peptides and the general principles for peptide designs.The research of self-assembling peptide scaffolds in tissue engineering is described in detail.