摘要
目的:研究金氏痔痛贴对实验性大鼠的止血作用。方法:将清洁级SD大鼠随机分为6组,即对照组、云南白药组、赋形剂组及金氏痔痛贴大、中、小剂量组,测定大鼠的凝血时间、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fg)值及血小板聚集功能。结果:金氏痔痛贴能显著缩短模型大鼠的凝血时间、PT、TT、APTT,并能增强大鼠的血小板聚集功能,均具有统计学意义(P<0.01),但对于Fg,不具有统计学意义(P>0.05),金氏痔痛贴上述指标与云南白药组相比,不具有统计学意义(P>0.05)。结论:金氏痔痛贴能显著缩短凝血时间、PT、TT和APTT,并能增强大鼠的血小板的聚集功能,该药具有良好的止血作用。可作为临床痔疮出血的止血药物,其止血机制可能与促进凝血过程中的凝血酶原和凝血活酶的生成、增强血小板的聚集功能有关。
Objective： To investigate the hemostatic effects of Jin＇s hemorrhoid patch.Methods：Sixty rats were randomly divided into six groups：normal control group,Yunnan Baiyao group,excipient group and Jin＇s hemorrhoid patch high-dose,medium-dose and low-dose groups.The changes of coagulation time were compared among six groups.The values of PT、TT and APTT were determined.Platelet aggregative function in rats was detected.Results：Jin＇s hemorrhoid patch could reduce coagulation time of model rats and the levels of PT、TT and APTT in rats,and it could enhance platelet aggregative function in rats.Conclusion：Jin＇s hemorrhoid patch can reduce coagulation time and it can be used for hemorrhoid bleeding.Hemostatic mechanism is associated with the production of plasmozyme and thrombokinase in the coagulation of blood and platelet aggregative function.
出处
《中华中医药学刊》
CAS
2012年第5期1113-1115,共3页
Chinese Archives of Traditional Chinese Medicine
基金
温州市科技局基金资助项目(Y20080134)
