结核分枝杆菌喹诺酮类耐药基因研究进展

Advances on target gene mutation in quinolones-resistance mycobacterium tuberculosis

日益增多的耐喹诺酮类结核分枝杆菌给结核病疫情的控制带来了巨大挑战,深入研究结核分枝杆菌喹诺酮类耐受机制便成为应对挑战的关键。药物靶基因突变是导致结核分枝杆菌喹诺酮类耐受的主要因素,近年来该方面的研究逐步受到重视并取得了一些进展,本文特对此进行述评。

A challenge for TB control is an increasing number of quinolones-resistant mycobactertum tu- berculosis. It is necessary for us to further investigate the mechanism of quinolones-resistance in mycobacteri-um tuberculosis. Mutation in target gene is the primary cause resulting in quniolones-resistance and attracts more attention in recent years. So we are going to review some new findings on this topic and give readers some advices for in-depth research.