枳实薤白桂枝汤对高脂血症大鼠血脂及血管内皮功能的影响

The Effect of Zhishi Xiebai Guizhi Decoction on Lipid Metabolism and Vscular Endothelium in Hyperlipidemia Rat

目的:观察枳实薤白桂枝汤对高脂血症大鼠血脂及血管内皮功能的影响。方法:以高脂饲料喂养建立高脂血症大鼠模型;分正常、模型、西药组、不同剂量中药干预组,共6组;西药组给予普伐他汀钠(3.6 mg·kg-1)灌胃,中药干预分别给予高(7.2 g·kg-1)、中(3.6 g·kg-1)、低剂量(1.8 g·kg-1)枳实薤白桂枝汤灌胃3周;测定总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c);一氧化氮(NO)、内皮素(ET-1)的含量。结果:与正常组比较,模型组大鼠血清TC,TG,LDL-C均显著升高(P<0.01),HDL-C降低(P<0.05);血清NO水平降低(P<0.05),血浆ET-1水平升高(P<0.05)。与模型组相比,普伐他汀钠组、枳实薤白桂枝汤高剂量组TC,TG,LDL-C均显著降低(P<0.01),枳实薤白桂枝汤中、低剂量组TC,LDL-C均降低(P<0.05),中剂量组TG降低(P<0.05);用药各组对HDL-C均无明显影响。普伐他汀钠组、枳实薤白桂枝汤高剂量组NO明显升高(P<0.05),普伐他汀钠组ET-1明显降低(P<0.05)。结论:枳实薤白桂枝汤可明显降低高脂血症大鼠TC,TG和LDL-C含量,提高血清NO水平,对ET-1的释放没有明显影响。枳实薤白桂枝汤具有降血脂及部分改善血管内皮功能的作用。

Objective： To investigate the effects of Zhishi Xiebai Guizhi decoction on lipid metabolism and vseular endothelium in hyperlipidemia rat. Method： Using hyperlipidemia animal model replicated by hyperlipidemia forage, pravastatin sodium （3.6 mg· kg^-1 ） and different doses of Zhishi Xiebai Guizhi decocotion （7.2, 3.6, 1.8 g· kg^-1 ） were given to the model rats. Then the levels of total cholesterol （TC） , triglycerides （TG）, high-density liporotein cholesterol （HDL-C） , low-density lipoprotein cholesterol （LDL-C） and levels of nitric oxide （NO）, endothelin-1 （ET-1） were assayed. Result： Compared with the normal group, the levels of TC, TG, LDL-C in the model group were increased obviously, the level of NO was decreased, the level of ET-1 was increased. Compared with the model group, the levels of TC, TG, LDL-C in the Zhishi Xiebai Guizhi deeocotion high dose group and the pravastatin sodium group were decreased obviously, the level of NO was increased obviously, the level of ET-1 were decreased obviously. Conclusion： The Zhishi Xiebai Guizhi decoeotion can regulate the lipid metabolism and improve vascular endothelium function in rat with hyperlipidemia.