自然流产病人抗ACA和抗DNA抗体分析

Detection of Anti-Cardiolipin Antibody and Anti-DNA Antibody in 56 Patients with Recurrent Spontaneous Abortion

目的 :探讨抗心磷脂抗体 (ACA)及抗DNA抗体检测在反复自然流产 (RSA)诊断中的意义。 方法 :应用ELISA法检测 5 6例RSA病人血清ACA与抗DNA ,与对照组 38例比较。 结果 :RSA组ACA、抗ss DNA阳性率分别为 32 .1% (18/ 5 6 )、2 1.4% (12 / 5 6 )较对照组 5 .2 % (2 / 38)、5 .2 % (2 / 38)明显增高 (P <0 .0 1)。三种类别ACA以IgG、IgM型检出率高 ,抗ds DNA阳性率为 3.5 % (2 / 5 6 )。 结论 :ACA及抗ss DNA与RSA密切相关 ,抗ds DNA对诊断RSA无明显意义。

Objectives:To explore the significance of anticardiolipin antibody(ACA) and anti DNA antibody in diagnosis of recurrent spontaneous abortion(RSA). Methods:Serum ACA and anti DNA in 56 patients with RSA were detected with ELISA and compared with those in 38 controls. Results:The positive rates of ACA and anti ss DNA in RSA group were 32.1%(18/56) and 21.4%(12/56) respectively, which were notably higher than those (5.2% and 5.2%) in the control group( P <0.01).The detectable rates of ACA of IgG and IgM types were relatively higher while the positive rate of anti ds DNA was 3.5%(2/56). Conclusions:ACA and anti ss DNA were closely related to RSA,while anti ds DNA was of no obvious significance in diagnosis of RSA.