地特胰岛素、甘精胰岛素联合亚莫利对2型糖尿病肥胖及非肥胖患者血糖及体重的影响

Effects of insulin detemir and insulin glargine combined with Amaryl on blood glucose and body weight in obese and non-obese type 2 diabetic patients

目的评价地特胰岛素(Det)、甘精胰岛素联合亚莫利治疗24周对2型糖尿病肥胖及非肥胖患者血糖及体重的影响。方法选择新诊断2型糖尿病60例,其中,男40例,女20例,肥胖30例,非肥胖30例,分别应用地特胰岛素(n=30)、甘精胰岛素(n=30)联合亚莫利治疗,肥胖30例随机分在地特胰岛素组和甘精胰岛素组各15例,比较两组治疗前后及两组间体重、空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、低血糖发生率,计算BMI、胰岛素用量。结果两组血糖均下降,但地特胰岛素组降糖效果更明显,且低血糖发生率低,对BMI的控制优于甘精胰岛素组。结论与甘精胰岛素组相比,地特胰岛素治疗新诊断2型糖尿病疗效更好,低血糖发生率低,体重控制优于甘精胰岛素。

Objective To evaluate the effects of insulin detemir and insulin glargine combined with Amaryl on blood glucose and body weight in obese and non-obese type 2 diabetic patients.Methods 60 cases of the newly diagnosed type 2 diabetes had been chosen to take insulin detemir（n = 30） versus insulin glargine（n = 30） combined with Amaryl treatment separately.Within 60 cases were 40 males and 20 females,and divided into two groups which included 30 obese and 30 non-obese cases separately.Figures of weight,FBG,2hPG,HbA1c and the incidence of hypoglycemia had been compared between groups.Results The levels of blood glucose were decreased in two groups,with more efficacy of glucose decreasing,less hypoglycemia,better control of BMI in insulin detemir versus insulin glargine.Conclusion The insulin detemir has a better efficacy and lower incidence of low blood glucose in treating newly diagnosed type 2 diabetic patients,and a better control of body weight compared with insulin glargine.