摘要
microRNA(微小RNA)是一类长度为17～25 nt的单链非编码RNA,能够识别特定的目标mRNA,并在转录后水平对基因的表达起负调控作用。血液、粪便及大肠癌组织中的microRNA可以辅助诊断大肠癌和预测疾病复发。特异microRNA的过度表达或沉默与大肠癌的发生、发展有关。组织和血液中特异microRNA的表达不同,提示了其在大肠癌早期发现和筛检中的应用前景。众多研究提示,microRNA与大肠癌的化疗药物敏感性有关。此外,mi-croRNA在大肠癌发生、发展过程中的作用表明其可能是重要的基因治疗目标。
MicroRNA is a kind of non-coding single-stranded RNA of about 17-25 nt, which could recognize specific mRNA targets, and mediate post-transcriptional repression of gene. MicroRNA may plays a role in colorectal cancer （CRC） diagnosis and recurrence prediction in blood, stool and tumor tissue. Over-expression or silence of specific mieroRNAs are tight related with the progress of CRC. An increasing number of studies had demonstrated that mieroRNA may affect the chemosensitivity of tumor cells. Furthermore, the action of microRNA in the development and progress of CRC indicates that mieroRNA is probably to be a significant target of the gene therapy.
出处
《中国医药导报》
CAS
2012年第15期8-10,23,共4页
China Medical Herald
