摘要
给麻醉兔iv SCD(杀虫单)7.5mg/kg可完全抑制自主呼吸和腓总神经胫前肌标本诱发的肌收缩;ivDMPS(二巯基丙磺酸钠)2.4、3.4、4.9mg/kg可使自主呼吸暂时恢复,但肌收缩恢复不全;iv DMPS7和10mg/kg使自主呼吸和肌收缩均恢复完全。ivDMPS62.5mg/kg可完全拮抗清醒兔SCD(7.5mg/kg)所产生的中毒症状而存活;当;v SCD大于12.5mg/kg出现惊厥时,DMPS合用安定显示较好的解救作用。
In peroneal nerve-anterior tibialis muscle preparations of uretbane anesthetized rabbits, sodium ammonium dimethyl-2 -( propano-1 , 3 - dithiosulfonate ) monohydrate ( SCD ) 7 .5mg/kg iv depressed the antogenous respiration completely and the indirectly elicited twitch tension completely finally. Sodium 2, 3 - dimercaptopropane- 1-sulfonate ( DMPS ) 7、 10mg/kg iv,respectively completely antagonized the respiratory depression and the neuromuscle block, DMPS (2.4、 3.4、 4.9mg/kg, iv ) could antagonize these toxic effects partly. DMPS (62.5mg/kg ,iv)could antagonize the toxic symptom induced by SCD(7.5 mg/kg, iv)in rabbits. At dose level higher than 12.5mg/kg of SCD, this toxin caused tremor and tonic convulsion. e Wfound DMPS (62.5 mg/kg, iv ) combined with diazepam ( 5mg/kg, iv ) has antidotal effects on acute poisoning caused by SCD in rabbits.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第6期371-374,共4页
Chinese Pharmacological Bulletin
关键词
ivDMPS
杀蝉
中毒
解毒剂
DMPS
SCD
Poisoning
Dose-effect relationship,Drug
Tranqilizing agents
Neuromusclar blocking agents
Convulsions