中枢神经系统感染儿脑脊液内皮素、血栓烷及前列环素的意义

Significance of the concentration of cerebrospinal fluid endothelin,thromboxane A 2 and prostacylin in children with infection of the central nervous system

目的 探讨内皮素 (ET1 )、血栓烷 (TXA2 )和前列环素(PGI2 )在小儿中枢神经系统感染 (FCNS)中的意义。方法 采用放射免疫方法检测 FCNS儿脑脊液 (CSF)中 ET1 及 TXA2 和 PGI2 的稳定代谢产物 TXB2 和 6 - k-PGF1α,非感染手术儿 CSF为对照。结果 FCNS儿 CSF、ET1 、TXB2 及 TXB2 /6 - k- PGF1α(T/K)比值升高 ,昏迷儿 CSF、ET1 、TXB2 高于非昏迷儿 ,恢复期 CSF、ET1 、TXB2 /6 - k- PGF1α比值较急性期下降。结论 FCNS时神经系统 ET1 和 TXA2 生成增加 ,CSF中 ET1 、TXB2 和 6 - k- PGF1α改变可反映脑实质损伤程度 ,有助于临床病情判断。

Objective To study the role of endothelin(ET 1),thromboxane A 2(TXA 2),and prostaglandin I 2(PGI 2)in central nervous system infection of children. Methods The concentrations of thromboxane B 2(TXB 2)and 6 keto prostaglandin F 1α ,the waste products of TXA 2 and PGI 2 respectively,and ET 1 in cerebrospinal fluid(CSF) samples from the children with or without(control) infection of the central nervous system were measured by radioimmunoassay. Results The concentrations of ET 1,TXB 2 and TXB 2/6 k PGF 1α ratio in CSF were increased in the children with infection of central nervous system,and began to decrease in their recovery phase.The concentrations of ET 1,and TXB 2 were higher in coma cases than in non coma cases. Conclusion The present study suggests that more ET 1 and TXA 2 are produced in infected nervous system.The changes of the concentations of ET 1,TXB 2 and 6 k PGF 1α in CSF may reflect the severity of cerebral lesion.