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替吉奥的作用机制及临床应用的研究发展 被引量:16

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摘要 目的探讨替吉奥治疗胃肠道肿瘤以及联合化疗药物对其他瘤种治疗的方案。方法通过替吉奥的单药临床试验以及联合其他化疗药品的多中心试验对有效率、生存率、安全性进行分析比较。结果有效率提高、生存率提高、不良反应减轻。结论替吉奥可代替5-氟尿嘧啶(5-FU)治疗胃癌,还可以联合其他化疗药品治疗肠癌、肺癌。
出处 《中外医疗》 2012年第13期109-110,共2页 China & Foreign Medical Treatment
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参考文献12

  • 1Malet-MartinoM,MartinoR.Clinicalstudiesofthreeoralprodrugsof5-fluorouracil(capecitabine,UFT,S- 1):Areview[J].Oncologist,2002,7 (4):288- 323.
  • 2HoffPM.Thetega fur-baseddihydropyrimidinedehydrogena seinhibitory fluoropyrimidines,UFT/leucovorinandS- 1 : Areviewoftheirclinicaldevelopmentandtherapeuticpotential[ J]. InvestNewDuag,2000,18(4):331 - 342.
  • 3马培奇.胃癌治疗新药替吉奥钾研究进展[J].上海医药,2010,31(5):228-230. 被引量:5
  • 4金懋林.胃癌内科化学治疗的新进展[J].医学临床研究,2003,20(10):735-738. 被引量:68
  • 5马培奇.抗肿瘤新药替吉奥钾研究进展[J].上海食品药品监管情报研究,2007(6):30-33. 被引量:9
  • 6Mitsuru Sasako,TairaKinoshita,HiroshiFurukawa,et.Five- yearresultsoftherandomizedphasellItrialcomparingS- 1 monotherapyversussurgeryaloneforstagelI/ IIIgastriccancerpatientsaftercurativeD2 gastrectomy(ACT S- GCstudy). [J].Journalo fClinicaOncology,2011,36:5908.
  • 7李小平,郑磊贞.含替吉奥联合化疗方案治疗进展期胃癌研究的进展[J].临床肿瘤学杂志,2009,14(11):1048-1051. 被引量:39
  • 8WasaburoK,HiroyukiN,TakuoH,et al.S- 1 pluscisplatinversusS- 1 aloneforfirst-lineTreatmentofadvancedgastriccancer (SPIRITStrial):aphasellltrial[J].TheLancetOncology,2008,9(3): 215-221.11.
  • 9JinM,LuH,LiJ,et al.Randomized3-armedphaseIIIstudyofS- 1 monother apyver sus S - 1/CDD P( SP)ver su s5 -FU/C DD P (FP) INpatients(pts)withadvancedgastriccancer(AGC): SC 101 study[J]. JClinOncol,2008,26:a4553.
  • 10Y.Komatsu,S.Yuki,S.Sogabe,et al,PhaselITrialofCombined Chemotherapywithlrinotecan,S- 1 ,andBevacizumabinPatientswith MetastaticColorectalCancer[J].ESMO,2010: 5.

二级参考文献20

  • 1Cunningham D,Allum WH,Stenning SP,菅鑫妍.手术期间化学疗法与单独手术治疗可切除的胃食管癌疗效比较[J].中国处方药,2006,5(8):59-60. 被引量:434
  • 2Malet-Martino M,Martino R.Clinical studies of three oral prodrugs of 5-fluorouracil(capecitabine,UFT,S-1):A review[J].Oncologist,2002,7(4):288-323.
  • 3Hoff PM.The tegafur-based dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines,UFT/leucovorin and S-l:A review of their clinical development and therapeutic potential[J].Invest New Drugs,2000,18(4):331-342.
  • 4白坂哲彦 佃守 犬山征夫 他.新規経口抗癌剤TS-1(S-1).癌と化学瘵法,2001,28(6):855-864.
  • 5Hirata K,Horikoshi N,Aiba K,et al.Pharmacokinetic study of S-1,a novel oral fluorouracil antitumor drug[J].Clin Cancer Res,1999,5(8):2000-2005.
  • 6Sakuramoto S,Sasako M,Yamaguchi T,et al.Adjuvant chemotherapy for gastric cancer with S-1,an oral fluoropyrimidine[J].NEnglJMed,2007,357(18):1810-1820.
  • 7Maehara Y.S-1 in gastric cancer:A comprehensive review[J].Gastric Cancer,2003,6(Suppl 1):2-8.
  • 8Nagashima F,Ohtsu A,Yoshida S,et al.Japanese nationwide post-marketing survey of S-l in patients with advanced gastric cancer[J].Gastric Cancer,2005,8(1):6-11.
  • 9Koizumi W,Narahara H,Hara T,et al.S-l plus cisplatin versus S-l alone for first-line treatment of advanced gastric cancer(SPlRITS trial):A phase Ⅲ trial[J].Lancet Oncol,2008,9(3):215-221.
  • 10Ajani JA,Rodriguez W,Bodoky G,et al.Multicenter phase 3 comparison of cisplatin/S-1 (CS) with cisplatin/5-FU (CF) as first-line therapy in patients with advanced gastric cancer (FLAGS)[EB/OL].http://www.asco.org/ASCOv2/Meetings/ Abstracts?&vmview=abst_detail_view&confID=63&abstractID= 10388,January 6,2010.

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