中国淋巴瘤亚型分布:国内多中心性病例10002例分析

Distribution pattern of lymphoma subtypes in China: A nationwide multicenter study of 10002 cases

目的:采用国内多中心性合作,回顾性分析10 002例淋巴瘤病例的临床和病理资料,以探讨我国淋巴瘤流行病学特点。方法:组织全国范围内的合作研究,选择来自24家有代表性的医学机构的10 002例淋巴瘤病例,复习其病理切片和临床资料,并作总结分析。结果:10 002例淋巴瘤患者中,男性6188例,女性3814例,男女比为1.6∶1;中位年龄54岁;活检标本取自结外部位相较淋巴结活检略为多见,结内与结外病变比例为1∶1.2。我国人群最常见的淋巴瘤类型是弥漫性大B细胞淋巴瘤(非特指性)(占所有淋巴瘤的33.27%),滤泡性淋巴瘤较西方人群相对少见,而T细胞及NK细胞淋巴瘤在我国人群相对多见(占所有淋巴瘤的21.38%),霍奇金淋巴瘤占所有淋巴瘤的构成比为8.54%,且最常见的亚型为混合细胞型和结节硬化型。结论:我国淋巴瘤亚型分布有其独特特征。

Objective To assess the prevalence of lymphoma subtypes in China via a nationwide multicenter study of lymphoma cases.Methods Ten thousand and two cases of malignant lymphoma diagnosed at 24 representative medical centers in China were collected and the clinical and pathologic data were analyzed.Results The patients comprised 6188 males and 3814 females（with a male to female ratio of 1.6∶1）,with a median age of 54 years（range 1-95,average 50.4）.Biopsy specimens from extranodal sites were slightly more common than nodal ones（with a nodal to extranodal ratio of 1∶1.2）.Diffuse large B-cell lymphoma,not otherwise specified,（DLBCL,NOS） was the commonest subtype（comprising 33.27% of all lymphomas）,whereas follicular lymphoma was less common when compared with Western countries.T /NK-cell lymphoma appeared more prevalent（comprising 21.38% of all lymphomas） in Chinese population.Hodgkin lymphoma accounted for 8.54% of all the lymphomas and the most common subtypes are mixed cellularity and nodular sclerosis.Conclusions A unique characteristic distribution pattern of lymphoma subtypes is observed in Chinese population.