米非司酮用于腹腔镜下宫外孕保守手术治疗临床疗效观察

CLINICAL OBSERVATION ON MIFEPRISTONE IN CONSERVATIVE OPERATION OF ECTOPIC PREGNANCY BY LAPAROSCOPE

目的研究宫外孕患者口服米非司酮药物治疗后行腹腔镜下保守手术治疗的疗效评价。方法 2008—2010年以"异位妊娠"诊断收入院要求行宫外孕保守手术治疗的123例患者为研究对象,按照随机分组原则分为二组。治疗组63例,术前米非司酮50mg/次,2次/d,共口服3d。服药后手术治疗。对照组60例;入院后完善相关检查,无禁忌直接行手术治疗。结果治疗组出血量少,手术时间短,术后β-hCG值下降速度明显快于对照组。术后患侧输卵管功能明显优于对照组。结论宫外孕患者口服米非司酮药物治疗后行腹腔镜下保守手术治疗,能有效保护患侧输卵管功能。

Objective To investigate the effect of mifepristone in conservative operation of ectopic pregnancy by laparoscope. Methods One hundred and twenty- six patients who underwent laparoscope primary surgery for tubal pregnancy in center hospital of NanYang between 2008 and 2010 were included in the study. The patients were randomized divided into two groups：therapy group （n = 63） with mifepristone 50mg Bid po, together three days befor the operation;Control group （n = 60） with direct conservative opera- tion. The two groups were all given laparoscope conservative operation. Results Compared with control group,the bleed was few and the time of operation was short in therapy group, the decay rate of human chorionic gonadotrop（β- hCG） was also obviously quick in therapy group. The function of oviduct after op- eration was improved in therapy group than control group. Conclusion Given mifeprist to patients with ec- topic pregnancy befor laparoscope eonservative operation can utility preserve the function of undergoing conservative surgery underwent tubal.