国产和进口丁咯地尔对局部脑缺血影响的比较性研究

COMPARASION OF THE EFFECTS OF DOMESTIC AND IMPORTED BUFOLMEDIL ON LOCAL CEREBRIAL ISCHEMIA

目的 :观察灌胃和静脉注射丁咯地尔对大鼠局部脑缺血的影响并比较国产和进口品的异同。方法 :采用电凝闭塞大脑中动脉引起局部脑梗塞 ,测其给药后行为和梗塞范围的大小以判断药物的作用。结果 :灌胃 2 5 ,5 0和 75mg/kg及静脉注射国产和进口丁咯地尔 3,6和 12mg/kg均能使电凝闭塞大脑中动脉引起的大鼠行为障碍明显减轻 ,脑梗塞范围 (以重量计 )明显缩小并呈剂量依赖关系。结论 :丁咯地尔具有明显的改善脑缺血引起的行为改变并有缩小脑梗塞范围的作用 。

OBJECTIVE: To investigate the protective effects of domestic and imported buflomedil on local cerebral ischemia in rats and to compare their effecacy METHODS: Local cerebral ischemia model in rats was established by permanent occlusion of the proximal of the left middle cerebral artery (MAC) and the drug effects was determined by measurement of rats′ behavior after drug administration and the infarct area RESULTS: Both domestic and improted buflomedil in doses of 25, 50 and 75 mg/kg ig or 3, 6, and 12 mg/kg iv,can reduce the seize of infarct area and ameliorate the neurological deficit score of rats CONCLUSION: The same protective effect on local cerebral ischemia was achieved by both domestic and imported buflomedil