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吗氯贝胺与丙咪嗪治疗抑郁症的随机双盲对照研究 被引量:5

A RANDOMIZED DOUBLE BLIND CONTROLLED STUDY ON THE EFFEICACY OF MOCLOBEMIDE AND IMIPRAMINE IN TREATMENT OF DEPRESSION
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摘要 目的 :采用吗氯贝胺和丙咪嗪治疗抑郁症的双盲对照试验 ,同时对吗氯贝胺进行开放临床研究。方法 :15对双盲和 30例开放的临床研究 ,采用疗前和疗后第 1,2 ,4,6周末进行HAMD ,HAMA ,TESS及CGI的评定。结果 :吗氯贝胺组、丙咪嗪组、吗氯贝胺开放组HAMD减分率分别为 6 9 3% ,83 6 % ,75 6 % ,前二者经统计学分析组间无差异性 (P >0 0 5 ) ;各组内治疗前后HAMD得分均有差异性 (P <0 0 5 )。 3组显效率分别为 80 % ,93 3% ,90 % ,前二者经统计学分析组间无差异性 (P >0 0 5 )。 3组出现的不良反应基本相似。结论 :吗氯贝胺是一种安全、有效的抗抑郁药 。 OBJECTIVE: In comparison to effect of moclobemide and Imipramine treating depression METHODS: 15 pares were givn by double blind research and 30 cases were by open research Effect was valued by HAMA, HAMD, CGI and safety was valued by TESS at 2,4,6 weekend of after treating and before treating RESULTS: Decrease rate of HAMD in moclobemide group was 69 3% and in imipramine group was 83 6% There was no difference of decrease rate of HAMD between two groups in statistics ( P >0 05) There was a significant difference of HAMD total score between before treating and after treating in two groups ( P <0 05) Significant improvement rate was 80% in moclobemide group and 93 3% in imipramine group There was no difference of improvement rate between two groups Decrease rate of HAMD was 75 6% and improvement rate was 90% in moclobemide open group Side effect were similar among above three groups CONCLUSION: Moclobemide is a safe and effective anti depressive drug and it is worthy of widely usement
出处 《中国新药杂志》 CAS CSCD 2000年第2期112-114,共3页 Chinese Journal of New Drugs
关键词 吗氯贝胺 丙咪嗪 抑郁症 治疗 Moclobemide Imipramine Depression
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