5124例腹泻患者临床治疗效果回顾性分析

Retrospective Analysis of Clinical Treatment for 5124 Cases of Diarrheal Diseases

目的:研究腹泻临床治疗方法及其效果,为腹泻的治疗提供依据。方法:对2011年中国知网学术文献总库中收录的关于腹泻临床治疗的文献进行总结,并按照国际用药调研指标体系中的特定疾病用药指标进行分类,对临床效果进行分析。结果:文献共计报道5124例腹泻治疗病例,其中使用口服补液盐1458例,占28.5%;使用止泻药1080例,占21.1%;使用抗生素996例,占19.4%;使用微生态调节剂649例,占12.7%;使用其他疗法941例,占18.4%。口服补液盐使用率明显高于另外4组,差异有统计学意义(P<0.05)。使用口服补液盐的临床总有效率最高(84.7%),其次为使用抗生素治疗,总有效率66.4%,微生态制剂以及止泻药的总有效率分别为50.5%和48.9%,口服补液盐的临床效果明显好于另外4组,差异有统计学意义(P<0.05)。结论:腹泻的治疗以口服补液盐为主,其次为止泻药和抗生素治疗,既有单独治疗方案,也有联合治疗的报道。从治疗结果上看,应用口服补液盐临床总有效率高,治疗效果好,值得在临床中广泛应用。

OBJECTIVE： To investigate the clinical treatment for diarrhea and their effects, and to provide the basis for the treatment of diarrhea. METHODS： Literatures on clinical treatments of diarrhea involved in CNKI in 2011 were searched and summarized. All treatments for diarrhea were classified in accordance with specific disease drug use index in international drug use research index system, and then clinical effects were analyzed. RESULTS： There were 5 124 reports on treatment of diarrhea. 1 458 cases were given oral rehydration salts therapy, about 28.5% ; there were 1 080 cases with antidiarrheal drugs, about 21.1% ; and 996 cases were treated with antibiotics, about 19.4% ; 649 cases used microecological regulating agents, about 12.7% ; 941 cases received other therapy, about 18.4%. The utilization ratio of oral rehydration salts was significantly higher than other therapies, there was statistical significance （P〈0.05）; in comparison of clinical effects, the total effective ratio of oral rehydration salts was the highest （84.7%） , followed by antibiotics （66.4%） , microecological regulating agents （50.5%） and antidiarrheal drugs （48.9%）; clinical effects of oral rehydration salts was significantly better than other 4 programs, there was statistical significance （P〈0.05）. CONCLUSIONS： The main treatment of diarrhea is oral rehydration salts therapy, followed by antidiarrheal drugs and antibiotics. Both combination and separation program have been reported. According to the effects of treatment, oral rehydration salts therapy is the most effective method with the highest effective ratio, and it is worthy of clinical use.