单纯疱疹病毒检测在宫颈疾病中的价值

Study on significance of high-risk type HSV antibody testing in screening of cervical diseases

目的探讨单纯疱疹病毒(HSV)感染在宫颈疾病中的临床特点以及价值。方法采用酶联免疫吸附试验(ELISA)对患者血清标本进行单纯疱疹(HSV-1及HSV-2)特异性病毒抗体(IgM)检测。结果 1095例患有子宫颈糜烂、滴虫性和霉菌性阴道炎及淋病患者血清标本HSV-IgM阳性检出率分别为32.5%、23.4%、15.7%、22.8%,除淋病组与滴虫组、霉菌组与淋病组比较差异无统计学意义外,其他几组都有HSV感染率均有显著性差异。378例宫颈糜烂患者根据程度不同HSV阳性率分别为16.6%、33.6%、43.5%,三组之间有显著性差异,且随糜烂程度加重HSV阳性率增高。86例不同病理分型患者HSV阳性检出率分别为26.1%、40%、50、62.5%,HSV阳性检出率随病理分级严重程度呈趋势增高,但无显著性差异。结论 HSV感染可以与上述疾病单发或混合感染,HSV是宫颈疾病发生、进展的关键因素之一;HSV感染的检测对妇女生殖疱器疹的诊断及治疗,对围产医学和优生优育等工作均有重大作用。

Objective To evaluate clinical features and significance of herpes simplex virus infection in patients with cervical diseases.Methods Serum levels of anti-HSV-1 and anti-HSV-2 specific IgM antibodies in patients were detected by using enzyme-linked immunosorbent assay（ELISA）.Results The positive rates of serum anti-HSV-IgM in 1095 patients with cervical erosion,gonorrhea,trichomoniasis or fungal vaginitis were 32.5%,22.8%,23.9% and 15.6% respectively.There was significant difference in HSV infection rates among patients in all groups except gonorrhea group with trichomoniasis group and fungus infection group with gonorrhea group.The positive rates of anti-HSV-IgM in 378 patients with different degrees of cervical erosion were 16.6%,33.6% and 43.5% respectively,and there was significant difference among these three groups.The positive rate of anti-HSV IgM was raised following the increase in degree of severity of erosion.The positive rates of anti-HSV IgM in 86 patients with different pathological types were 26.1%,40%,50 and 62.5% respectively,and the positive detection rate of anti-HSV IgM showed a tendency of increased severity with pathological grades,but there was no significant difference between them.Conclusion Above-mentioned data demonstrated that HSV could be infected alone or mixed infected,and HSV infection is an important factor responsible for the pathogenesis and progress of cervical lesions.The detection of HSV infection is important for diagnosis and treatment of blister rashes in reproductive organs of women,and it plays a significant role in health work for perinatal,prenatal and postnatal care.