急性脑梗死患者血浆Lp-PLA2和hs-CRP水平及意义被引量：20

Plasma levels of lipoprotein-associated phospholipase A2 and high-sensitivity C-reactive protein in patients with acute cerebral infarction and their clinical significances

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摘要目的探讨血浆脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)及超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与急性脑梗死患者脑梗死体积、神经功能缺损程度的关系。方法收集急性脑梗死患者(62例)和未卒中对照者(26例),采用酶联免疫吸附法检测血浆Lp-PLA2水平,免疫速率散射比浊法检测hs-CRP水平。计算脑梗死体积并行神经功能缺损程度评估。结果 Lp-PLA2水平随脑梗死体积增加而呈递增趋势,差异无统计学意义;hs-CRP水平随脑梗死体积增加而呈递增趋势,差异有统计学意义;Lp-PLA2及hs-CRP水平随神经功能缺损程度增加而呈递增趋势,差异有统计学意义;经相关性分析Lp-PLA2和hs-CRP水平无相关性。结论急性脑梗死患者血浆Lp-PLA2水平升高与神经功能缺损程度有关,而与脑梗死体积无关;hs-CRP水平升高与神经功能缺损程度及脑梗死体积有关。 Objective To explore the relationship between the plasma levels of lipoprotein-associated phospholipase A2 （ Lp-PLA2 ） and high-sensitivity C-reactive protein （hs-CRP） in patients with acute cerebral infarction and the volume of cerebral infarction, the severity of neurological impairment. Methods Patients with acute cerebral infarction （n = 62）and non-stroke controls （ n= 26） were studied. The plasma levels of Lp-PLA2 were detected by enzyme linked immunosorbent assay and the levels of hs-CRP were detected by the rate nephelometry method. The volumes of cerebral infarction were calculated and the severities of neurological impairment were assessed. Results The plasma levels of Lp-PLA2 raised with the increasing of the volume of cerebral infarction, but the differences of interclass had no statistical significance. The levels of hs-CRP raised with the volume of cerebral infarction and the differences of interclass had statistical significances ; The levels of Lp-PLA2 and hs-CRP raised with the exacerbating of neurological impairment, the differences of interclass had statistical significances; By linear correhion analysis the plasma levels of Lp-PLA2 were not correlated with the levels of hs-CRP.Conclusion Patients with acute cerebral infarction have higher plasma levels of Lp-PLA2. Ithas relationship with the severity of neurological impairment, but nothing to do with the volume of cerebral infarction ; Patients with acute cerebral infarction have higher plasma levels of hsCRP. It has relationship with the severity of neurological impairment and the volume of cerebral infarction.

作者朴海金永华

机构地区哈尔滨医科大学附属第二医院神经内科

出处《哈尔滨医科大学学报》 CAS 北大核心 2012年第3期266-269,共4页 Journal of Harbin Medical University

关键词急性脑梗死脂蛋白相关磷脂酶A2 超敏C反应蛋白 acute cerebral infarction lipoprotein-associated phospholipase A2 high-sensitivity C-reactive protein

分类号 R743.3 [医药卫生—神经病学与精神病学]

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