联合检测血清IL-6、IL-18及IL-18BP在原发性肝癌中的临床价值

Clinical Value of Determination of IL-6,IL-18 and IL-18 BP in Patients with Primary Liver Cancer

目的探讨联合检测血清IL-6、IL-18及IL-18BP在原发性肝癌的诊断、分期及治疗中的临床价值。方法采用ELISA法检测肝癌患者血清中的IL-6、IL-18及IL-18BP水平。结果①肝癌组血清IL-6、IL-18BP明显高于肝良性肿瘤组、肝硬化组及正常对照组;血清IL-18明显低于肝良性肿瘤组、肝硬化组及正常组,差异有统计学意义(P<0.05);②在临床早期,血清IL-6、IL-18BP比临床晚期水平低,而血清IL-18水平较临床晚期高,差异有统计学意义(P<0.05);③肝癌患者手术后血清IL-18水平较手术前有明显的升高,而血清IL-6、IL-18BP较手术前有所降低,差异有统计学意义(P<0.05);④血清IL-6、IL-18、IL-18BP与AFP有相关性(P<0.01)。结论联合检测血清IL-6、IL-18及IL-18BP,可以作为原发性肝癌的血清辅助诊断及临床分期提供有效的参考价值,有可能为肝癌患者的靶向治疗提供潜在靶点。

Objective To explore clinical value of the determination of serum IL-6,IL-18 and IL-18 BP in diagnosis,classification and treatment of the primary liver cancer.Methods The expression levels of IL-6,IL-18 and IL-18 BP in liver cancer patients were detected by ELISA test.Results ①The levels of sIL-6 and sIL-18BP of liver cancer group were significantly higher those of the liver benign tumor group,liver cirrhosis group and normal control group,the sIL-18 level was significantly lower than that in the control groups and the patients with various benign liver tumor or LC（P0.05）.②Early in the clinical stage,levels of serum IL-6,IL-18BP were lower than those of late clinical stage,but serum level of IL-18 was higher than that in late clinical stage（P0.05）.③Serum IL-18 level in liver cancer patients after surgery increased significantly than that before the operation,but levels of serum IL-6,IL-18BP reduced after operation（P0.05）.④The levels of serum IL-6,IL-18 and IL-18BP had correlation with AFP（P0.01）.Conclusion The detection of serum IL-6,IL-18 and IL-18BP can provide a valid reference value for diagnosis and clinical stage of the primary liver cancer,it may become potential target for the targeting therapy of liver cancer.