复方桑寄生钩藤配方颗粒与汤剂的药效学比较研究

Pharmacodynamics of formula granules and traditional decoction of compound Sangjisheng Gouteng

目的进行复方桑寄生钩藤配方颗粒与汤剂的药效学比较。方法从高脂血症模型大鼠血脂(TG、TC、HDL-C)、血压(SP、DP)、心脏系数、肝脏系数、体重5个方面的8个指标考察复方桑寄生钩藤配方颗粒与汤剂药理作用的差异。结果同剂量比较,复方桑寄生钩藤配方颗粒能显著降低大鼠体重、TC、TG、收缩压、舒张压,显著升高HDL-C;汤剂组除能显著升高大鼠HDL-C,降低大鼠舒张压作用外,对其余各项指标均无明显影响。结论复方桑寄生钩藤配方颗粒的降脂降压等药理作用明显强于汤剂。

Objective To compare the difference in pharmacodynamics from formula guanules and traditional decoction of compound Sangjisheng Gouteng. Methods We compared the difference in pharmacodynamics from formula granules and traditional decoction of compound Sangjisheng Gouteng from blood lipid （TG, TC and HDL-C）, blood pressure （SP and DP）, weight, heart coefficient and liver coefficient in hyperlipidemic rats. Results The formula granule group effectively lowered the weight, TC, TG, systolic blood pressure （SD）, diastolic blood pressure （DP） and ef- fectively increased HDI：C in hyperlipidemic model rats. The traditional decoction group only lowered the diastolic blood pressure and increased HDL-C in hyperlipidemic model rats. Conclusion The pharmacological effect of compound Sangjishenggouteng formula granule is stronger than the traditional decoction in lowering blood lipid and blood pressure in hyperlipidemic model rats.