加减益经汤对有卵泡型卵巢早衰的临床研究

Clinical Observation and Study on Modified Yijing Decoction in Treating Premature Ovarian Failure

目的:探讨加减益经汤治疗治疗有卵泡型卵巢早衰的疗效和机理。方法:将90例有卵泡型卵巢早衰患者随机分为3组。治疗组采用自拟加减益经汤治疗,对照1组组采用人工周期治疗,对照2组采用维生素C片联合复合维生素B片治疗,观察患者治疗后临床疗效改善情况,血清FSH、LH、E2、INH-b的含量。结果:加减益经汤治疗本病临床疗效总有效率为63.63%,痊愈率为6.06%,显效率为18.18%,临床症状显著改善,显示本方具有改善卵巢储备功能、降低血清FSH、LH水平、升高E2、INH-b的作用。结论:加减益经汤治疗本病,是通过提高卵巢储备功能而实现的。

Objective：To study the mechanism and effects of Modified Yijing Decoction in treating Premature ovarian failure that ovarium secreted ovarian follicle.Methods：The patients collected 90 cases of Premature ovarian failure that ovarium secreted ovarian follicle were stochastically divided into three groups.The patients in treatment group were treated with traditional Chinese medicine Modified Yijing Decoction.The patients in control group one were treated with artificial periodic therapy and the patients in the other control group were treated with vitamin C tablets and compound vitamin B tablets therapy.Before and after treatment were observed in patients with improvement of clinical effects,the concentration of blood follicle-stimulating hormone（FSH）,luteinizing hormone（LH）,estradiol（E2） INH-b.Results：The overall clinical efficacy rate of Modified Yijing Decoction in treating Premature ovarian failure was 63.63%,the cure rate was 6.06%,the marked improvement rate was 18.18%.The significant improvement of clinical symptoms showed that the prescription had the effects of improving ovarian reserve,decreasing the concentration of blood follicle-stimulating hormone,luteinizing hormone and increasing the concentration of plasma E2 INH-b.Conclusion：Modified Yijing Decoction in treating Premature ovarian failure was put into effect by improving ovarian reserve.