临床分离猪链球菌和副猪嗜血杆菌多重耐药性监测

Monitoring of multiple resistance of Streptococcus suis and Haemophilus parasuis strains from clinical isolates

为了解我国规模化猪场链球菌和副猪嗜血杆菌的耐药情况,用纸片扩散法对临床分离的112株猪链球菌和92株副猪嗜血杆菌进行23种药物的敏感性试验。结果表明,猪链球菌对林可胺类、大环内酯类、硝基呋喃类药物的耐药率均在90%以上,对链霉素、庆大霉素、卡那霉素、阿米卡星、多西环素的耐药率在60%～90%之间,而对β-内酰胺类和氟喹诺酮类的耐药率相对较低。副猪嗜血杆菌对四环素耐药率最高(78.3%),对螺旋霉素、复方磺胺甲噁唑、克林霉素、阿米卡星、林可霉素、新霉素的耐药率在50%～70%之间,对头孢类和氟喹诺酮类耐药率相对较低。2种细菌对不同种类药物的敏感性各异,并且多重耐药性严重,主要耐药谱具有多样性。

One hundred and twelve Streptococcus suis and 92 Haemophilus parasuis were isolated from pig farm to investigate susceptibility of the two bacteria strains to 23 antimicrobials by using disk diffusion method. Results showed that for the S. suis strain,the resistance rates of lincosamide, macroli- des and nitrofurans were all above 90%, followed by streptomycin, gentamicin,kanamycin, amikacin and doxyeycline with the resistance rates ranged from 60% to 90% and resistance rates of β-1actams and quinolones were relatively lower. For the H. parasuis strain, the resistance rate of tetracycline was the highest （78. 3%）, followed by spiramycin, sulfamethoxazoie/TMP, clindymycin, lincomycin, amikacin and neomycin varied from 50% to 70% and resistance rates of cephalosporins and quinolones were rela- tively lower, The susceptibility of the two kinds of bacteria to the antimicrobials were different, multiple resistance was severe and the resistance profiles were various.