质子泵抑制剂联合莫沙必利治疗反流性食管炎的疗效观察

The effect observation of proton pump inhibitor cobined with mosapride treatment of reflux esophagitis

目的观察质子泵抑制剂联合莫沙必利治疗返流性食管炎的临床疗效。方法以2009年12月至2011年12月间宜宾市第一医院收治的74例RE患者为研究对象,将患者随机分为雷贝拉唑组(给予雷贝拉唑+莫沙必利治疗)和奥美拉唑组(给予奥美拉唑+莫沙必利治疗),雷贝拉唑组38例,奥美拉唑组36例。结果 74例RE患者经过8周的治疗,雷贝拉唑组患者的症状改善总有效率为97.4%,奥美拉唑组的总有效率为83.3%,两组有效率比较,差异具有统计学意义(P<0.05);经内镜检查,雷贝拉唑组患者的总有效率为97.4%,奥美拉唑组的总有效率为72.2%,两组有效率比较,差异具有统计学意义(P<0.05)。结论雷贝拉唑+莫沙必利治疗RE临床症状改善迅速,其临床疗效优于奥美拉唑+莫沙必利组。

Objective Clinical efficacy of the observed proton pump inhibitor combined with mosapride treatment of reflux esephagitis. Methods Yibin City in December 2009 to December 2011 the hospital treated 74 cases of patients with RE as the research object. Patients were randomized to the mbeprazole group （ Give rabeprazole ＋ mosapride）and omeprazole（ Give omeprasole ＋ Mosapride） ,rabeprazole group of 38 cases, 36 cases of omeprasole. Results 74 RE patients after 8 weeks of treatment,rabeprazole grotip of patients with symptom improvement for the total effective rate was 97.4% ,83.3% of the total effective rate of the omeprazole group. Two sets of efficiency compared to a statistically significant difference （ P 〈 0. 05 ） ; By endoscopy, the rabeprazole group of patients with a total effective rate was 97.4% ,72. 2% total effective rate of the omeprazole group, Two sets of efficiency compared to a statistically significant difference （ P 〈 0. 05 ）. Concltsion Rabeprazole ＋ mosapride RE clinical symptoms improve rapidly, its clinical efficacy is superior to omeprasole ＋ mosapride group.