期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人类埃柯病毒6的基因特征分析 被引量：3

Genetic Characteristics of Echovirus 6
原文传递
导出
摘要 目的对来自10个国家和中国4个省不同时间分离的69株ECHO6病毒VP1区基因特征进行分析。方法在GenBank,EMBL和DDBJ 3个基因库中进行BLASTN搜索,共得到69株ECHO6病毒基因可用,用Mega软件计算病毒基因同源性并构建基因进化树。结果 69株ECHO6病毒可分为4个基因型(基因型A～D),C基因型又可分为7个亚型,D基因型可分为8个亚型。不同毒株的核苷酸差异率为10.6%～24.5%(氨基酸差异率为0.8%～7.3%),不同基因型之间的核苷酸差异率为17.6%～22.4%(氨基酸差异率3.5%～6.6%)。结论 ECHO6不同基因型/亚型可以在同一个地区流行很长时间,同一时间内不同的基因型/亚型又可在不同的地区流行,具有明显的时间和地域流行特点。 Objective To analyze the genetic characteristics of VP1 zone in 69 strains of echovirus 6（ECHO6） isolated from 10 countries and 4 provinces in China at different time.Methods BLASTN searched in GenBank,EMBL and DDBJ,totally 69 ECHO6 strains were available in the study;the genetic similarity and phylogenetic tree were done by Mega softaware.Results Sixty-nine ECHO6 strains were divided into 4 genotypes（A-D）,genotype C was further divided into 7 subgenotypes and genotype D into 8 subgenotypes.The sequence diversity between different strains was 10.6%-24.5%（aa diversity was 0.8%-7.3%）,and between different genotypes was 17.6%-22.4%（aa diversity was 3.5%-6.6%）.Conclusion ECHO6 prevalence in different genotypes/subtypes could last for a long time,and at the same time in different genotypes/subtypes could also prevalent in different regions,with significant time and geographical characteristics.
作者 田炳均 丁峥嵘 陆林 汤晶晶 张杰 罗梅
机构地区 云南省疾病预防控制中心免疫规划科
出处 《预防医学情报杂志》 CAS 2012年第7期510-514,共5页 Journal of Preventive Medicine Information
关键词 埃柯病毒6型 基因特征 echovirus 6（ECHO6）； genetic characteristics；
分类号 R512.39 [医药卫生—内科学]
  • 相关文献

参考文献17

  • 1Caro V, Guillot S, Delpeyroux F, et al. Molecular strategy for'serotyping' of human enteroviruses [ J ]. J Gen Virol, 2001,82 ( Pt 1 ) :79-91.
  • 2Norder HL, Magnius LO. Homotypic echoviruses share aminoterminal VP1 sequence homology applicable for typing [ J ]. J Med Virol, 2001,63( 1 ) :35-44.
  • 3Oberste MA,Pallansch MA. Typing of human enteroviruses by partial sequencing of VP1 [ J ]. J Clin Microbiol, 1999,37 (5) : 1288 -1293.
  • 4Oberste MR, Pallansch MA. Molecular evolution of the human entero- viruses:correlation of serotype with VP1 sequence and application to picomavirus classification[ J ]. J Virol. 1999.73 (3) : 1941-1948.
  • 5Abe O, Kimura H, Minakami H, et al. Outbreak of gastroenteritis caused by echovirus type 6 in an orphanage in Japan[ J]. J Infect, 2000,41 (3) :285-286.
  • 6] Cabrerizo M, Echevarria JE, Gonzlez I, et al. Molecular epidemiologi- cal study of HEV-B enteroviruses involved in the increase in menin- gitis cases occurred in Spain during 2006[ J]. J Med Virol,2008,80 (6) :1018-1024.
  • 7Mao N,Zhao L, Zhu Z,et al. An aseptic meningitis outbreak caused by echovirus 6 in Anhui province, China [ J ]. J Med Virol, 2010,82 (3) :441445.
  • 8Ventura KC, Hawkins H, Smith MB, et al. Fatal neonatal echovirus 6 infection:autopsy case report and review of the literature [ J ]. Mod Pathol, 2001,14 ( 2 ) : 85 -90.
  • 9李幸乐,黄学勇,许汴利,陈豪敏,唐晓燕,杜燕华,晁灵.病毒性脑炎病例中Echo6河南分离株VP1基因特征分析[J].中华流行病学杂志,2011,32(4):425-427. 被引量：8
  • 10Fares W, Rezig D, Seghier M ,et al. Phylogenetie analysis of complete VP1 sequences of echoviruses 11 and 6 : high genetic diversity and circulation of genotypes with a wide geographical and temporal range [J]. J Med Microbiol,2001,60(Pt 7):1017-1025.

二级参考文献12

  • 1王海岩,徐爱强,朱贞,李岩,纪峰,张勇,张丽,许文波.无菌性脑膜炎暴发中Echo30病毒的基因特征及分子进化分析[J].中华流行病学杂志,2006,27(9):793-797. 被引量：19
  • 2ZHEN ZHU,WEN-BO XU,AI-QIANG XU,HAI-YAN WANG,YONG ZHANG,LI-ZHI SONG,Hui-LiYANG,YANLI,FENGJI.Molecular Epidemiological Analysis of Echovirus 19 Isolated From an Outbreak Associated With Hand, Foot, and Mouth Disease (HFMD) in Shandong Province of China[J].Biomedical and Environmental Sciences,2007,20(4):321-328. 被引量：22
  • 3Stanway G,Brown F, Christian P, et al. Picornaviridae In Virus Taxonomy. Eighth Report of the International Committee for the Taxonomy of Viruses//Edited by Fauquet CM, Mayo MA, Maniloff J, et al. Ball. Elsevier Academic Press, San Diego, 2005 : 757-763.
  • 4Norder H, Bjerregaard L, Magnius L, et al. Sequencing of ‘untypable' enteroviruses reveals two new types, EV-77 and EV-78,within human enterovirus type B and substitutions in the BC loop of the VP1 protein for known types. J Gen Virol, 2003,84(4) :827-836.
  • 5Oberste M,Schnurr D, Maher K, et al. Molecular identification of new picornaviruses and characterization of a proposed enterovirus 73 serotype. J Gen Virol,2001,82(2) :409-416.
  • 6Oberste MS,Maher K,Michele SM,et al. Enteroviruses 76,89,90 and 91 represent a novel group within the species Human enterovirus A. J Gen Virol,2005,86(2) :445-451.
  • 7Oberste MS,Michele SM,Maher K,et al. Molecular identification and characterization of two proposed new enterovirus serotypes,EV74 and EV75. J Gen Virol, 2004,85 ( 11 ) : 3205-3212.
  • 8CDC. Progress toward poliomyelitis eradication People' s Republic of China, 1990-1996. MMWR, 1996,45 (49) : 1076-1079.
  • 9Zhang J, Zhang LB, Otten MW, et al. Surveillance for polio eradication in the People' s Republic of China. J Infect Dis, 1997,175 Suppl 1 :S122-134.
  • 10陶泽新,李岩,王海岩,宋立志,刘桂芳,刘尧,林小娟,冯蕾,杨赫,樊庆莹,徐爱强.肠道病毒A组山东地方株的基因型分布[J].病毒学报,2009,25(6):410-414. 被引量：18

共引文献40

同被引文献35

引证文献3

二级引证文献2

预防医学情报杂志
2012年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部