摘要
目的研究成纤维细胞生长因子受体2(FGFR2)基因单核苷酸多态性(SNP)与乳腺癌相关性。方法对280例乳腺癌患者及280例健康女性进行ASA-PCR检测,分析其三个位点(rs2912778、rs2981582、rs2981578)SNP与乳腺癌风险关系。结果三个位点(rs2912778、rs2981582、rs2981578)基因型分布在乳腺癌组和对照组中差异具有统计学意义(P<0.05);与病理资料进一步联系分析,除rs2912778在淋巴结转移方面野生型与变异型差异具有高度统计学意义(P<0.01)之外,其余三个位点野生型与变异型相比差异均无统计学意义(均P>0.05)。结论 FGFR2基因三个位点单核苷酸多态性可能与乳腺癌的发生有关。
Objective To investigate whether single nucleotide polymorphisms (SNP) of fibroblast growth receptor 2 (FGFR2) are associated with breast cancer risk. Methods In the present study of 280 breast cancer patients and 280 cancer-free controls, we tested three FGFR2 polymorphisms (rs2981582, rs2981578A/G and rs2912778) the method of ASAPCR. Results Differences were found in the genotypes between the breast neoplasm group and the control group of all loci (P 〈 0.05). Among three loci, except rs2912778 (P 〈 0.01) in FGFR2 was related to lymph node metastasis, any difference between wild-type and variant-type in clinical pathological factors were not found (all P 〉 0.05). Conclusion The findings indicate that genetic variants in FGFR2 may contribute to breast cancer occurrence.
出处
《中国医药导报》
CAS
2012年第22期13-15,19,共4页
China Medical Herald
关键词
成纤维细胞生长因子受体2
单核苷酸多态性
乳腺癌
Fibroblast growth factor receptor 2
Single nucleotide polymorphism
Breast neoplasm