盐酸氨溴索治疗新生儿感染性肺炎的疗效观察

Observation on curative effect of Ambroxol Hydrochloride in the treatment of neonatal pneumonia

目的探讨盐酸氨溴索治疗新生儿感染性肺炎的疗效。方法 90例感染性肺炎的新生儿按照入院顺序分为治疗组和对照组,对照组采用常规治疗,治疗组在对照组的基础上雾化吸入盐酸氨溴索治疗,两组均以5 d为1个疗程,比较两组患儿的疗效、血氧饱和度、临床症状和体征恢复正常的时间。结果治疗组总有效率为88.9%,显著高于对照组的62.2%(P<0.05)。治疗组动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)的改善显著优于对照组(P<0.05),且治疗组的呼吸困难改善时间、吸痰次数、氧疗时间、住院时间均显著短于对照组(P<0.05)。结论盐酸氨溴索能够显著促进感染性肺炎新生儿排痰,改善通气,提高治疗效果。

Objective To investigate the curative effect of Ambroxol Hydrochloride in the treatment of neonatal pneumonia. Methods 90 cases of infectious pneumonia in the newborn were divided into the treatment group and the control group according to the order of hospitalization, the control group was given conventional treatment, the treatment group was given atomization inhalation of Ambroxol Hydrochloride, 5 d was needed for a course of treatment, two groups were compared with curative effect oxygen saturation, the time of clinical symptoms and signs return to normal time. Results The total effective rate was 88.9% in the treatment group, which was higher than 62.2% in the control group （P 〈 0.05）. In the treatment group, the improvement of arterial partial pressure of oxygen （PaO2） and arterial partial pressure of carbon dioxide （PaCO2） were significantly better than those in the control group （P 〈 0.05）. And dyspnea improved sputum suction time, frequency, oxygen therapy, duration of hospital stay in the treatment group were significantly shorter than that in control group （P 〈 0.05）. Conclusion Ambroxol Hydrochloride can significantly promote infection pneumonia of newborn sputum excretion, improve ventilation and the treatment effect.