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二氢吡啶类钙通道阻滞剂在慢性稳定性冠心病中应用中国专家共识 被引量:11

Chinese experts consensus on the application of dihydropyridine calcium channel blockers in chronic stable coronary artery disease
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摘要 引言 钙通道阻滞剂(CCB)是临床广泛应用的一类心血管药物。20世纪60年代,Fleckenstein发现CCB有抗心绞痛作用,1975年硝苯地平开始用于治疗心绞痛。1995年Furberg等根据短效硝苯地平小规模临床研究的荟萃分析,对CCB的安全性提出质疑。进一步分析发现,短效CCB增加心血管病死亡率的主要原因可能是血压快速下降而激活交感神经、增加血浆去甲肾上腺素(NE)水平,使心率增加,
出处 《中国心血管杂志》 2012年第4期241-244,共4页 Chinese Journal of Cardiovascular Medicine
关键词 二氢吡啶类 钙通道阻滞药 慢性稳定性冠心病 Dihydropyridines Calcium channel blockers Stable coronary artery disease
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