274例氯氮平片致不良反应病例分析

Analysis of 274 Cases of Adverse Drug Reaction Caused by Clozapine Tablets

目的分析274例氯氮平片致不良反应病例报告,探讨氯氮平片致不良反应的特点和规律,为临床安全合理用药提供参考。方法结合文献资料回顾分析274例氯氮平片致不良反应,尤其是严重不良反应进行综合分析。结果氯氮平片致不良反应涉及13个器官-系统损害,主要严重不良反应为以肝功能异常为主要表现的肝胆系统损害、以白细胞减少、粒细胞减少为主要表现的白细胞和网状内皮系统异常等。结论应关注氯氮平所致的严重不良反应,加强用药过程监护,减少药品带来的伤害。

Objective To probe into the general pattern and characteristics of ADRs induced by clozapine so as to provide references for clinic rational use of clozapine. Methods Combining the literature, review and retrospectively analyze 274 cases induced by clozapine. Results ADRs induced by clozapine involve thirteen organ-system damage, the major damages are the damage of the hepatobiliary system and abnormal white blood cells and the reticuloendothelial system, which usually manifest as abnormal liver function, leukopenia and neutropenia. Conclusion It should be strengthened to observe and evaluate the severe ADRs induced by clozapine. And the medication monitoring of clozapine should be enhanced in order to reduce the injury which the drugs bring.