限制输液量联合血压控制治疗食管胃底静脉曲张破裂出血的临床研究

Clinical investigation of restrict-dropping bottle combined with blood pressure-controled in treatment of esophageal and gastric varices bleeding

目的观察食管胃底静脉曲张破裂出血(EGVB)在药物止血的基础上,采取限制输液量联合血压控制(简称"减容止血")的综合治疗效果。方法将115例EGVB患者分成两组,其中56例采取限制输液量联合血压控制即减容、降压、止血疗法(简称"减容止血"),59例采取常规的治疗方法即扩容、止血、抗休克(简称"扩容止血"),对比分析两组的近期疗效。结果减容止血组8 h及24 h以内止血率提高,病死率降低。结论限制输液量联合血压控制的综合治疗,可明显提高EGVB患者止血成功率,很大程度上降低再出血率,近期临床疗效肯定。

Objective To investigate the effect of restrict-dropping bottle combined with control blood pressure in treat- ment of esophageal and gastric varices bleeding （EGVB） in patients with liver cirrhosis. Methods A total of 118 patients with acute hemorrhage from esophageal and gastric varices bleeding as a result of liver cirrhosis were randomLy classified into dropping bottle restriction haemostasis group 56 cases included and fluid expansion haemostasis group 59 cases included. Short term effect was contrasted. Results The effect of hemostasis in dropping bottle restriction patients was better than fluid expansion groups （P 〈 0.01）, while mortality was also significantly decreased in dropping bottle restriction group （P 〈 0.01） which were determined 8 and 24 h after treatment. Conclusion Restrict-dropping bottle combined with blood pressure-control can effectively decrease rehemorrhage and mortality in patients with acute hemorrhage from esophageal and gastric varices bleeding than that of fluid expansion haemostasis. It is affirmative for short term effect.