依那普利联合小剂量氢氯噻嗪治疗高血压疗效观察

The Curative Effect Observation of Enalapril Combined with Low-dose Hydrochlorothiazide in the Treatment of Hypertension

目的:研究依那普利联合小剂量氢氯噻嗪治疗高血压的疗效及对代谢的影响。方法:48例原发性高血压患者随机分为两组,对照组单用依那普利(依苏,扬子江药业)5～15mg,2次/d。治疗组用依那普利5mg,2次/d,加服氢氯噻嗪12.5mg,1次/d,两组治疗时间均为8周,测定治疗前后的基础血压、空腹血糖、血脂、血钾、血尿酸、尿素氮、肌酐以及治疗前后的24h动态血压。结果:治疗组总有效率及24h动态血压均明显优于对照组,而且两组治疗前后的代谢指标均无明显改变。结论:依那普利联合小剂量氢氯噻嗪治疗高血压较单用依那普利更有效,而且对代谢无明显影响。

Objective ：To study the effect of enalapril combined with low-dose hydrochlorothiazide in treatment of hypertension and its effect on metabolism. Methods ：48 cases of primary hypertension were randomly divided into two groups, control group（enalapril in Su, the Yangtze River Pharmaceutical）5-15 rag, two times every day.The treatment group with enalapril in 5 rag, 2 times every day, plus hydrochlorothiazide 12.5 mg, one time every day, two groups were treated for 8 weeks.Blood pressure, 24 hour ambulatory blood pressure, metabolic parameters such as fasting blood glucose, blood lipid, blood potassium, urea nitrogen and creatinine were evaluated before and after drug therapy.Results ：The total effective rate of the treatment group and 24 h ambulatory blood pressure was superior to the control group, but the metabolic index of two groups before and after treatment did not change significantly.Conclusion ：Enalapril combination with low-dose hydrochlorothiazide are more effective than Enalapril alone in the treatment of hypertension, and have no significant influence on metabolism.