医用镁合金降解及其对人体的影响

Medical magnesium alloy degradation and its impact on human physiology

镁合金具有比高分子更高的强度、比陶瓷材料更好的韧性,与人体自然骨的密度、弹性模量和力学性能也更为接近。更重要的是,其植入人体后将会逐步腐蚀降解,既无毒副作用也无需二次手术,是一种极具潜质的新型可降解生物金属材料。但镁在人体生理环境中腐蚀速度太快,可能导致镁离子、氢气、局部pH值和腐蚀沉淀物在体内发生堆积,同时镁合金的机械完整性和力学性能也会因此丧失,达不到预期的治疗目的,甚至引起不良反应和治疗失败。从镁在人体的腐蚀机理和降解产物对人体造成的影响进行综述,并分析了镁合金在未来的发展方向和挑战。

Magnesium alloy has a higher strength than the polymer, better toughness than ceramic materials, and the density,elastic modulus and mechanical properties are also closer to the body＇s natural bone, More im- portantly, magnesium alloy can be corrossed and degradated after implanted into the human body,neither cause side effects do not need the second surgery, so it was considered as a great potential biodegradable materials. However,excessive corrosion rate of magnesium in the body＇s physiological environment will lead to magnesi- um ions, hydrogen and corrosion sediment accumulation in the body, the local pH value increased and the me- chanical structure was incomplete, reduce the treatment effect, and even cause adverse reactions and treatment failure. From the magnesium corrosion mechanism and degradation products in the human body impact were re- viewed and analyzed the magnesium alloy in the future development direction and challenges.