肾脏损伤中尿液C-反应蛋白检测价值分析

Clinical applications of urinary C-reactive protein in kidney injury

目的探究尿液C-反应蛋白(CRP)与肾脏损伤之间存在的关系及其在肾脏损伤检查中的应用价值,为临床诊断提供依据。方法根据患者病情将由于肾脏损伤导致肾功能不全而就诊的患者分为氮质血症期组、代偿期组、衰竭期组及终末期组,应用乳胶增强性散射比浊法对所有患者尿液中所含的白蛋白、CRP、转铁蛋白、免疫球蛋白G(IgG)及α1-微球蛋白等蛋白成分含量进行检测,并分析各种蛋白成分的含量与肾脏损伤间的关系。结果尿液中CRP的阳性率:氮质血症期组患者为55.95%,代偿期组为5.64%,衰竭期组为18.20%,终末期组为14.29%;其中氮质血症期组患者的检测阳性率明显高于其他组,差异均有显著性(P<0.01);CRP阳性组与阴性组进行比较发现患者尿液中IgG,α1-微球蛋白水平差异亦显著(P<0.01)。结论尿液CRP检测可有效反映肾病患者的肾脏损伤程度,在检测肾脏损伤及指导临床治疗方面具有良好的应用价值。

Objective To explore the relationship of urine C - reactive protein （CRP） with kidney damage and its value in the examina- tion of kidney damage in order to provide a basis for clinical diagnosis. Methods According to the patient＇s conditions the patient were divided into three groups ： azotemia group, decompensated group, failure stage group and end - stage phase group. Urine microalbumin, C - reactive protein, transferrin, IgG and α1 - microglobulin were detected by latex nephelometry method. Results CRP positive rates were 55.95% , 5.64% , 18. 20% and 14.29% in azotemia group, decompensated group, failure stage group and end - stage group respectively. CRP positive rate was signifi- cantly higher in azotemia group than those in other groups （ P 〈0.01 ）. There were also significant differences in IgG and α1 - microglobulin lev- els between CRP positive group and CRP negative group （ P 〈 0.01 ）. Conclusion Urine CRP test can effectively reflect the extent of kidney damage in kidney disease, the detection of urine CRP has good application value for the diagnosis and treatment of kidney damage.