孕酮及其受体与男性生殖

Progesterone and its receptor in male reproduction

孕酮是一种女性激素,它对女性生理功能及妊娠有着很重要的作用。近年来发现孕酮及其受体与男性生殖也有关。在男性生殖腺中存在孕酮受体mRNA。孕酮通过与其受体结合调节精子的产生,促进精子受精,而在少精、弱精、畸形精子症和不明原因不育男性精子中,孕酮受体的表达缺陷及其对孕酮的反应性降低导致受精能力下降。本文综述了孕酮及其受体与男性生殖的研究进展。

Progesterone,as a female hormone,plays an important role in the physiological function and pregnancy maintenance in women.Recent studies show that progesterone and its receptor are also involved in male reproduction,and its receptor mRNA exists in male sexual glands.It is believed that progesterone,binding to its receptor,can regulate spermatogenesis and improve the fertilization of sperm,while the sperm from those with oligospermia,asthenonzoospermia,teratazoospermia or unexplained infertility exhibit a low fertility due to the deficient expression of the progesterone receptor and insensitive reaction to progesterone.This review focuses on the progress in the studies of progesterone and its receptor in male reproduction.Natl J Androl,2012,18（9）： 840-842