进展期胃癌术后早期复发的临床病理因素分析

Analysis of Clinicopathological Factors of Early Recurrence in Patients with Advanced Gastric Carcinoma Postoperation

[目的]探讨进展期胃癌术后复发的时间和影响因素。[方法]回顾性分析155例进展期胃癌术后复发患者的临床病理资料,采用χ2检验进行单因素分析,Logistic回归进行多因素分析进展期胃癌患者术后复发的相关因素。[结果]155例患者平均复发时间为术后12.6个月。其中早期复发(距首次手术≤1年)94例(60.6%),晚期复发(距首次手术>1年)61例(39.4%)。单因素分析显示,胃癌术后早期复发与肿瘤直径、Borrmann分型、分化程度、浸润深度、淋巴结转移、TNM分期有关(P<0.05)。多因素Logistic结果显示,TNM分期和淋巴结转移是进展期胃癌术后早期复发的独立危险因素(P<0.05)。[结论]TNM分期和淋巴结转移是预测进展期胃癌术后早期复发的重要因素。

[Purpose] To investigate the time and influencing factors of recurrence in patients with advanced gastric cancer postoperation.[Methods] Clinicopathological data of 155 patients with ad-vanced gastric cancer postoperative recurrence were analyzed retrospectively with χ 2 test and mul-tivariate Logistic regression analysis.[Results] The mean time of recurrence was 12.6 months from primary surgery.Patients were divided into early recurrence group（recurrence within one year after surgery） 94 cases（60.6%）;and late recurrence group（recurrence ≥1 year after surgery） 61 cases（39.4%）.Univariate analysis showed that the tumor diameter,Borrmann type,differentiation,depth of invasion,lymph node metastases and TNM staging correlated to the time of recurrence（P0.05）.Multivariate Logistic regression analysis showed that TNM staging and lymph node metastases were independent factors related to early recurrence（P0.05）.[Conclusion] TNM stage and lymph node metastases are important factors to predict early recurrence in patients with advanced gastric cancer postoperation.