血管紧张素转化酶抑制剂用于阿尔茨海默病合并高血压的探讨

Discussion on Angiotensin converting enzyme inhibitors in treatment of Alzheimer's disease combined with hypertension

目的探讨血管紧张素转化酶抑制剂治疗阿尔茨海默病合并高血压的临床疗效。方法选取本院80例阿尔茨海默病合并高血压的患者,将其分为治疗组和对照组,每组各40例。对照组给予尼群地平治疗,治疗组给予尼群地平联合依那普利治疗。观察两组患者血压变化及简易智能精神状态检查量表(MMSE)的评定结果 ,并比较两组疗效。结果经过治疗后,治疗组收缩压与舒张压均低于对照组(P<0.05);治疗组治疗后MMSE各项指标评分均高于对照组,治疗组MMSE总分高于与对照组比较(P<0.05)。结论血管紧张素转化酶抑制剂治疗阿尔茨海默病合并高血压具有较好的疗效,值得临床推广应用。

Objective To discuss the clinical effect of Angiotensin converting enzyme inhibitors in treatment of Alzheimer＇s disease combined with hypertension.Methods Eighty cases of patients with Alzheimer＇s disease combined with hypertension in our hospital were selected,and divided into treatment group and control group,each group had 40 cases.Control group was given Nitrendipine,and treatment group was given Nitrendipine combined with Enalapril.The change of blood pressure and the scores of mini mental state examination （MMSE） of two groups were observed,and the clinical effects of two groups were compared.Results After treatment,systolic blood pressure and diastolic blood pressure of treatment group were lower than that of control group （P0.05）,Index score of MMSE and the total score of MMSE in treatment group were higher than that of control group （P0.05）.Conclusion Angiotensin converting enzyme inhibitors in the treatment of Alzheimer＇s disease combined with hypertension has a good curative effect,and it is worthy to use in clinic.