摘要
用 3.0和 1.0 g浸膏 / kg 2个剂量进行试验 ,探讨单味栀子 75 %甲醇提取物对炎症组织的影响 ,结果表明 ,栀子浸膏可显著抑制醋酸诱发血管通透性增加 ,高、低剂量的抑制率分别为 44 .7%和 2 5 .6 % ;显著抑制角叉菜所致大鼠足肿胀作用 ,第 6小时抑制率分别为 33.6 %和 2 5 .4% ;显著抑制棉球肉芽组织增生 ,抑制率分别为 5 4.1%和 33.0 % ;对醋酸诱发的小鼠扭体反应有一定抑制作用 ,抑制率分别为 2 6 .8%和18.9%。
The antiinflammatory and analgesic effects of a 75% methanolic extract of Gardenia jasminoides Ellis were studied at a high dose (3 0 g/kg) and a low dose (1 0 g/kg) in experimental animals. Results showed that the extract significantly inhibited the increase of dye exudation induced by acetic acid of 44 7% and 25 6%; significantly inhibited carrageenin induced rat paw edema of 33.6% and 25.4% at 6 h; significantly inhibited cotton pellet induced granuloma formation of 54.1% and 33.0%; reduced the number of writhes induced by acetic acid of 26.8% and 18.9% at high and low doses respectively. These results indicated that the 75% methanolic extract obtained from G. Jasminoides have significant antiinflammatory and analgesic effects.
出处
《中草药》
CAS
CSCD
北大核心
2000年第3期198-200,共3页
Chinese Traditional and Herbal Drugs
关键词
桅子
抗炎
镇痛
中药
Gardenia jasminoides Ellis antiinflammatory effect inflammatory exudation paw edema proliferation of granuloma writhing symptom