摘要
目的:探讨降脂Ⅱ制剂对实验性高脂血症家兔的降脂及抗动脉粥样硬化作用。方法:采用高脂饲料喂养家兔建立高脂血症和动脉粥样硬化模型,分为对照组、模型组、辛伐他汀组(2.2 mg·kg-1)、降脂Ⅱ制剂高、中、低剂量组(生药量4.6,2.3,1.2 g·kg-1),ig给药,每日1次。给药8周后测定血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、一氧化氮(NO)和内皮素-1(ET-1)含量;取主动脉,观察动脉斑块面积并进行病理学检查。结果:降脂Ⅱ制剂可明显降低血清TC,TG,LDL,ET-1含量(P<0.05,0.01),提高HDL,NO含量(P<0.05,P<0.01),缩小斑块面积、减轻动脉粥样硬化程度。结论:降脂Ⅱ制剂对家兔实验性高脂血症及动脉粥样硬化具有明显的抑制作用。
Objective: To study the effects of Jiangzhi II Preparation on experimental hyperlipemia and atherogensis in rabbits. Method: The hyperlipemia and atherosclerosis model in rabbits was established by feeding high-fat diet. All animals were randomly divided into normal group, model group, simvastatin group, Jiangzhi II high, middle and low dose groups (4.6, 2.3, 1.2 g .kg-1 ). After eight weeks of treatment, the content of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), nitric oxide (NO) and endothelin (ET-1) in serum were determined. The extent of aortic atherosclerosis was observed and the pathological examination was done. Result: In the Jiangzhi II treatment groups, the concentration of TC, TG, LDL, ET-1 in serum was decreased markedly, the the extent of aortic atherosclerosis and the atherosclerotic Preparation can effectively decrease the serum lipids and concentration of HDL and NO was increased remarkably, lesion were lightened obviously. Conclusion: Jiangzhi II prevent the formation of atherosclerosis.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第23期230-233,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
高脂血症
动脉斑块
家兔
三酰甘油
高密度脂蛋白
hyperlipemia
the extent of aortic atherosclerosis
rabbits
triglyceride
high density lipoprotein