保心胶囊对实验性犬心肌缺血血流动力学的影响

Effect of Baoxin capsule on hemodynamics of myocardial ischemia in dogs

目的 :观察保心胶囊对结扎犬心肌缺血时心脏血流动力学的影响。方法 :实验分假手术对照组 ,缺血组 ,缺血 +地奥组 ,缺血 +保心低剂量组 ,缺血 +保心中剂量组 ,各组犬连续灌胃 (生理盐水或药物 )三天后 ,结扎犬心脏冠脉左前降支复制急性心肌缺血模型 ,测定犬不同时点的血压、血流量及左室等容期压力最大变化速率的变化。结果 :保心中剂量组对血压、血流量及左室等容期压力最大变化速率的作用与缺血组比较有显著差异 (P <0 .0 5 )。结论 :保心胶囊具有改善心肌缺血。

AIM: To observe the effect of Baoxin capsules on hemodynamics of ischemic myocardium of dogs. METHODS: Fed Baoxin capsule for continuous three days, left anterior descending branch of the coronary artery of the dogs were ligated to observe the change of cardiac output, blood pressure and ±dp/dt max in different time of myocardial ischemia. RESULTS: Baoxin capsules increased the blood flow obviously, and increased left ventricular function simultaneously, the difference with ischemic group is significant (P<0.05). CONCLUSION: Baoxin capsules can improve myocardial ischemia and increase the cardiac contractility.