刺五加酸对酒精性肝损伤的影响

The Protective Effect of Acanthoic Acid on Liver Injury in Mice

目的:探讨刺五加酸(AA)对小鼠急性肝损伤的保护作用。方法:将60只小鼠随机分成6组,即正常组,乙醇模型组,水飞蓟素组(100 mg.kg-1),刺五加酸高、中、低剂量组(30,10,5 mg.kg-1)。小鼠每隔12 h给药1次,连续给药3次。每次给药后1 h,除正常组外均灌胃60%乙醇(5 g.kg-1)。观察大鼠血清的生化指标和病理组织变化。结果:在AA的高、中剂量组ALT(25±6),(31±8)U.L-1,AST(157±23),(187±18)U.L-1,TNF-α(32±4.62),(41±5.3)μg.L-1以及TG(190±23),(257±23)mmol.L-1明显下降,与模型组比较有显著性差异(P<0.001),减少了肝损伤程度。结论:刺五加酸对乙醇引起的小鼠急性肝损伤具有良好的保护作用。

Objective： To study the protective effects of acanthoic acid （AA） against acute liver injury. Method： Sixty mice were andomly divided into six groups： the normal group, the ethanol model group, silymarin group （100 mg ·kg^-1） , high-dose AA group （30 mg·kg^-1） , middle-dose AA group （10 mg ·kg^-1） and low-dose AA group （5 mg ·kg^-1）. Each group received medicine by gavage every 12 hrs for a total of 3 doses. Except for normal group, the other mice were received 60% ethanol （5 g ·kg^-1） 1 h. After administrayion. The thehepatic pathological and biochemical index changes in rats were observed. Result： The high-dose AA group and the middle-dose AA group can reduce the level of ALT （25±6）, （31 ±8） U · L^-1, AST （157±23）, （187 ±18） U·L^-1, TNF-α （32±4.62）, （41±5.3） μg·L^-1 and TG （190±23）, （257±23）mmol·L^-1, which was compared with the model group, and showed a significant difference （P 〈 0. 001 ）. Conclusion： The AA could protect mice from ethanol induced acute liver injury efficiently.