摘要
应用 3因素 5水平的均匀设计方法 ,研究了 β 环糊精对冰片的包合作用 .通过对包合物收率和包合率这二个指标的比较 ,筛选优化出冰片 β 环糊精包合物的最佳制备条件 ,在此条件下 ,分别采用 4种不同的包合方法制备冰片 β 环糊精包合物 ,结果以球磨法为最好 ,所得包合物的包合率和收率分别为 99 2 1%和 98 10 %
In this study 3 factors and 5 levels of conditions for the preparation of the borneol β CD inclusion complex were selected by the uniform design.The inclusion rate of borneol and recovery of inclusion complex were used as criteria in the test.An optimal condition was established.Under the optimal conditions the inclusion complex was prepared by 4 methods.The results showed that the ball grinding method was the best among the 4 methods.The inclusion rate of borneol and the yield of inclusion complex were 99 21% and 98 10%,respectively.
出处
《沈阳药科大学学报》
CAS
CSCD
2000年第3期170-173,共4页
Journal of Shenyang Pharmaceutical University
基金
辽宁省政府科学技术基金资助!No 9910 5 0 0 5 0 8
关键词
冰片
Β-环糊精
包合物
均匀设计
中药
borneol
β CD
inclusion complex
uniform design
preparation