龈沟液血管内皮生长因子水平与牙周病变临床指标的关系

Vascular endothelial growth factor level in gingival crevicular fluid in periodontal disease

目的探讨龈沟液中血管内皮生长因子(VEGF)与牙周病变主要临床指标的关系。方法选择牙周健康组12例,牙龈炎组12例,慢性牙周炎组24例(又分为静止期和活动期,各12例),采用酶联免疫吸附(ELISA)试验对龈沟液(gin-gival crevicular fluid,GCF)中VEGF的水平进行检测,数据采集完成后应用SPSS13.0软件进行统计学分析。结果健康牙龈、慢性龈缘炎、慢性牙周炎静止期至慢性牙周炎活动期位点GCF中VEGF水平逐渐升高(P<0.05),VEGF的浓度与牙龈指数(GI)、附着丧失(AL)呈正相关;其相关系数分别是0.341、0.325(P均<0.05),与牙周探诊深度(PD)(r=0.236,P>0.05)无相关。结论龈沟液中VEGF水平与牙周病变发展密切相关,VEGF水平有可能作为评价牙周组织炎性反应与破坏程度的参考标志。

Objective To study the relationship between the vascular endothelial growth factor（VEGF） level in gingival crericalar fluid（GCF） and periodontal clinical parameters.Methods The GCF samples were collected in 12 periodontally healthy individuals,12 gingivitis and 24 chronic periodontitis patients.VEGF levels in GCF were measured by enzyme-linked immunosorbent assay（ELISA）.The data were analyzed using SPSS13.0 software package.Results The VEGF concentrations were higher in patients with periodontal disease than in persons with healthy gingiva.There was a statistical difference between the four groups（P0.05）.The concentration of VEGF in GCF was positivly related to gingival index（GI） and attachment loss（AL） and not related to probing depth（PD）.Conclusions VEGF level in GCF is closly related progression of periodontal disease,and can be regarded as an useful index to reflect the status of periodontal disease.