炎症性肠病诱发骨质疏松症发病机制的研究进展

Research progress on pathogenesis of inflammatory bowel disease(IBD)-induced osteoporosis

骨质疏松症是炎症性肠病的晚期并发症之一。随着炎症性肠病的发生和发展,骨质疏松症的发病率逐渐增多。多种因素参与了炎症性肠病诱发骨量减少、骨质疏松,其中包括糖皮质激素、吸收不良及细胞因子等。因此,本文针对炎症性肠病诱发骨质疏松症的机制进行综述。

Decreased bone mineral density and osteoporosis is a frequent finding in patients with inflammatory bowel disease （IBD）. With the development of IBD, the incidence of osteoporosis is increasing. Many risk factors are involved in this process, including Malabsorption of vitamin D, calcium, vitamin K and other nutrients, steroid use and increase of inflammatory cytokines. In this review, we discuss the molecular pathways involved in the process of osteoporosis in IBD patients.