我院2009-2011年白色念珠菌检出率及其对氟康唑的耐药性变迁

Changes of the Detection Rate of Candida albicans and Its Drug Resistance to Fluconazole in Our Hospital from 2009 to 2011

目的:调查我院白色念珠菌的检出率及其对氟康唑耐药性的变化,为临床应用抗真菌药提供参考。方法:对我院2009-2011年白色念珠菌检出情况及其对氟康唑的耐药率进行统计分析。结果:我院2009-2011年念珠菌分离率上升了1.9%。白色念珠菌感染的病区分布以呼吸内科及老年病科最高,分别占43.0%、24.1%。3年间白色念珠菌在念珠菌中的构成比下降了5.8%,对氟康唑的耐药率上升了4.6%。结论:念珠菌分离率逐年增加;白色念珠菌在念珠菌中的构成比呈下降趋势,其对氟康唑的耐药率不断上升。临床应重视念珠菌的培养及药敏试验,合理使用抗真菌药。

To provide reference for the reasonable use of antifungal drugs in the clinic by investigating the changes of the detection rate of Candida albicans in our hospital as well as the shifts in the resistance rate of it to fluconazole. METHODS： The detection of Candida albicans and the resistance to fluconazole in our hospital from 2009 to 2011 were analyzed statistically. RESULTS： The isolation rate of Candida increased by 1.9%. The distribution rate of Candida albicans infection in respiratory department and geriatric department was the highest （43.0%, 24.1% ）. The constituent ratio of Candida albicans in Candida decreased by 5.8%, while the drug resistance ratio to fluconazole increased by 4.6% during the past three years. CONCLUSION： The isolation rate of Candida increase year by year, while the constituent ratio of Candida albicans is decreasing. The drug resistance rate to fluconazole increase constantly. Therefore, we should pay attention to the cultivation and drug sensitive tests of Candida and rational use of antifungal drugs.