单刀根对小鼠疼痛模型的影响

Experiment of Lysidice rhodostegia Hance on Mouse Pain Models

目的:用单刀根的生药超细粉末和不同溶媒提取物,经灌胃给予受试品后,考察该药材的镇痛作用。方法:以热刺激甩尾、热板法、扭体法、药物诱导痛经等致小鼠疼痛模型法,同时用耳肿胀法考察该药材的抗炎作用。结果:扭体实验各受试组与空白组相比,P<0.05,差异有统计学意义;热板法实验除单刀根水提液大剂量组,其它各提取物给药后痛阈值均有不是程度提高;痛经实验组与空白组扭体次数相比,差异有统计学意义。结论:实验表明,单刀根生药均有不同程度镇痛作用;同时其不同溶媒提取物均有对药物诱导小鼠痛经模型有一定镇痛作用。

Objective:To examine the analgesic effect of the stems,leaves,seeds and crude drug ultrafine powders and different solvent extracts of Lysidice rhodostegia Hance by intragastric administration on mouse pain models.Methods:Heat stimulation flick,hot plate,writhing,drug-induced pain were used to make mouse pain models and to observe the anti-inflammatory effect by making mouse ear swelling.Results:The various parts of Lysidice rhodostegia Hance had the analgesic effects at varying degrees except the tail flick by radiant heat stimulation in the pre-trial.The comparison of the subject group and the control group showed that P values were less than 0.05 and 0.01.In the pain experience model experiments,the different solvent extracts of the crude drug had the analgesic effect at varying degrees.Conclusion:The experiment showed that the crude drug has the analgesic effect at varying degrees and the different solvent extracts have certain analgesic effects on drug-induced mice pain models.